The Relationship between Aging and Heat Shock Response in the Inner Ear

衰老与内耳热休克反应之间的关系

• 批准号: 21592157
• 负责人: YAMASHITA Hiroshi
• 金额: $ 2.83万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592157/
• 关键词: 内耳; 老化; 熱ショック蛋白質; 加齢; 熱ショック応答

Mechanisms of age-related hearing loss have not been elucidated as aging processes are extremely complex. We examined age-related expression of HSPs in the cochlea of animal model of age-related hearing loss. The results showed that the mice showed weakening expression of Hsp70 and Hsp110 with age. In addition, we showed that hearing loss deteriorated in HSF1 null mice. These results demonstrate that the heat shock responses have a grate role in the age-related hearing loss

由于衰老过程极其复杂，与年龄相关的听力损失的机制尚未阐明。我们检查了年龄相关性听力损失动物模型耳蜗中 HSP 的年龄相关表达。结果显示，随着年龄的增长，小鼠的Hsp70和Hsp110表达减弱。此外，我们发现 HSF1 缺失小鼠的听力损失恶化。这些结果表明，热休克反应在与年龄相关的听力损失中具有重要作用

项目成果

老人性難聴における熱ショック応答の役割

热休克反应在老年性耳聋中的作用

• 发表时间: 2010
• 期刊: Otology Japan
• 作者: 菅原一真;原 浩貴;御厨剛史;橋本 誠;大久保公裕;山下裕司;菅原一真
• 通讯作者: 菅原一真

Unilateral intra perilymphatic infusion of sub-stance P facilitates vestibular functional recovery against AMPA-induced vestibulotoxicity

单侧外淋巴内输注 P 物质有利于前庭功能恢复，对抗 AMPA 诱导的前庭毒性

• 发表时间: 2010
• 作者: 山下裕司;下郡博明;豊田英樹;竹野研二;菅原一真;橋本誠
• 通讯作者: 橋本誠

The Strateies against the Hair Cell Degeneration with Otoprotective Molecules

耳保护分子对抗毛细胞退化的策略

• 发表时间: 2010
• 作者: Shojaku H;Watanabe Y;Takeda N;Ikezono T;Takahashi M;Kakigi A;Ito J;Doi K;Suzuki M;Takumida M;Takahashi K;Yamashita H;Koizuka I;Usami S;Aoki M;Naganuma H;Hiroshi Yamashita
• 通讯作者: Hiroshi Yamashita

Intratympanic Free Radical Scavenger(Edaravone) as Rescue Therapy in Sudden Sensorineural Hearing Loss

鼓室内自由基清除剂（依达拉奉）作为突发感音神经性听力损失的救援疗法

• 发表时间: 2011
• 作者: Kazuma Sugahara;Makoto Hashimoto;Takefumi Mikuriya;Hiroaki Shimogori;Hiroshi Yamashita
• 通讯作者: Hiroshi Yamashita

The Expression of Proinflammatory Cytokines After Acoustic Overexposure

声学过度暴露后促炎细胞因子的表达

• 发表时间: 2009
• 作者: Tetsuya Nakamoto;Yoshinobu Hirose;Takefumi Mikuriya;Makoto Hashimoto;Kazuma Sugahara;Hiroaki Shimogori;Hiroshi Yamashita
• 通讯作者: Hiroshi Yamashita