The development of mechanism and new therapy of the pruritis of atopic dermatitis.

特应性皮炎瘙痒的机制及新疗法的进展.

• 批准号: 21591468
• 负责人: TAKENAKA Motoi
• 金额: $ 3万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591468/
• 关键词: アトピー性皮膚炎; 神経ペプチド; サブスタンスP; neutral endopeptidase

Substance P is released from the sensory nerve of the skin, and it is known that substance P induce the inflammation of the skin. In the patient with the atopic dermatitis, when blood substance P was measured, substance P decreased by the standard treatment, and the m-RNA expression of degrading enzyme of substance P was enhanced. And, in the mouse which gave the stress, the contact hypersensitivity reaction enhanced, and L-selectin and substance P was indicated in the mechanism of enhanced response by the stress.

P物质由皮肤的感觉神经释放，已知P物质会引起皮肤炎症。在患有特应性皮炎的患者中，当测量血液P物质时，标准治疗后P物质减少，并且P物质降解酶的mRNA表达增强。并且，在给予应激的小鼠中，接触性超敏反应增强，并且L-选择素和P物质表明了应激增强反应的机制。

项目成果

Treatment With Rapamycin Prevents Fibrosis in Tight-Skin and Bleomycin-Induced Mouse Models of Systemic Sclerosis

• DOI: 10.1002/art.27498
• 发表时间: 2010-08-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Yoshizaki, Ayumi;Yanaba, Koichi;Sato, Shinichi
• 通讯作者: Sato, Shinichi

Rhizomucor variabilis infection in human cutaneous mucormycosis

• DOI: 10.1111/j.1365-2230.2010.03956.x
• 发表时间: 2011-04
• 期刊: Clinical and Experimental Dermatology
• 影响因子: 4.1
• 作者: H. Tomita;E. Muroi;M. Takenaka;K. Nishimoto;H. Kakeya;H. Ohno;Y. Miyazaki;A. Utani

A portable dermatoscope for easy, rapid examination of periungual nailfold capillary changes in patients wuth syatemic sclerosis

便携式皮镜，可轻松、快速地检查系统性硬化症患者甲周毛细血管的变化

• 发表时间: 2011
• 期刊: Rheumatol Int
• 影响因子: 4
• 作者: Muroi E;Hara T;Yanaba K;Ogawa F;Yoshizaki A;Takenaka M;Shimizu K;Sato S
• 通讯作者: Sato S

Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis

系统性硬化症患者体内针对细胞凋亡执行者 caspase-3 的自身抗体

• 发表时间: 2010
• 期刊: Rheumatol Int
• 影响因子: 4
• 作者: Okazaki S;Ogawa F;Iwata Y;Hara T;Muroi E;Komura K;Takenaka M;Shimizu K;Hasegawa M;Fujimoto M;Sato S
• 通讯作者: Sato S

Platelets Control Leukocyte Recruitment in a Murine Model of Cutaneous Arthus Reaction

• DOI: 10.2353/ajpath.2010.081117
• 发表时间: 2010-01-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Hara, Toshihide;Shimizu, Kazuhiro;Sato, Shinichi
• 通讯作者: Sato, Shinichi