Research for the progression of encapsulating peritoneal sclerosis

包裹性腹膜硬化的进展研究

• 批准号: 21591062
• 负责人: KAKUTA Takatoshi
• 金额: $ 2.91万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591062/
• 关键词: ピリドキサミン; 腹膜透析; 最終糖化産物; カルボニル化合物; メチルグリオキサール; 慢性腎不全; AGE; カルボニルストレス; 被嚢性硬化性腹膜炎(EPS); 終末化糖産物(AGE)

This study is to assess the efficacy of pyridoxamine against the peritoneal damage under induced by the peritoneal dialysis fluid. We administered pyridoxamine to the peritoneal damage and renal failure model rat. However, we couldn't prove this efficacy of the drug from some reasons, for example, rather minor damage of the peritoneum. We are currently on the re-experiment. Which intends to induce more damage on the peritoneum raising the dose of methylglyoxal, one of the Glucose degradation products. Concurrently, raising the dose of pyridoxamine to make the effect of pyridoxamine more definite. We also examined the pharmacokinetics of the drug with a small number of chronic renal failure patients on peritoneal dialysis. The pyridoxamine concentration in blood and subsequently, concentration of the drug in the peritoneal dialysis fluid effluent raised.

本研究旨在评估吡哆胺对抗腹膜透析液引起的腹膜损伤的功效。我们对腹膜损伤和肾衰竭模型大鼠施用吡哆胺。但由于某些原因，例如腹膜损伤较小，我们无法证明该药物的这种功效。目前我们正在进行重新实验。其目的是增加葡萄糖降解产物之一甲基乙二醛的剂量，从而对腹膜造成更多损伤。同时提高吡哆胺的剂量，使吡哆胺的作用更加明确。我们还通过少数接受腹膜透析的慢性肾功能衰竭患者检查了该药物的药代动力学。血液中的吡哆胺浓度以及随后腹膜透析液流出物中的药物浓度升高。

项目成果

Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advvanced Glycation End Products in Hemodialysis Patients

司维拉姆和钙基磷酸盐结合剂对血液透析患者冠状动脉钙化和循环晚期糖化终末产物积累的影响

• 发表时间: 2011
• 期刊: Am J Kidney Dis
• 影响因子: 13.2
• 作者: Kakuta;R. Tanaka;T. Hyoudou;H. Suzuki;G. Kanai;M. Nagaoka;H. Takahashi;N. Hirawa;Y. Ogushi;T. Miyata;H. Kobayashi;M. Fukagawa;A. Saito
• 通讯作者: A. Saito

Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients

• DOI: 10.1053/j.ajkd.2010.10.055
• 发表时间: 2011-03-01
• 期刊: AMERICAN JOURNAL OF KIDNEY DISEASES
• 影响因子: 13.2
• 作者: Kakuta, Takatoshi;Tanaka, Reika;Saito, Akira
• 通讯作者: Saito, Akira