Combination chemoprevention of hepatocellular carcinoma with acyclic retinoid by targeting RXRαphosphorylation

靶向 RXRα 磷酸化的无环维A酸联合化学预防肝细胞癌

基本信息

批准号：
21590838
负责人：
MORIWAKI Hisataka
金额：
$ 2.91万
依托单位：
Gifu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590838/
关键词：
非環式レチノイド核内受容体異常併用化学発癌予防肝細胞癌

项目摘要

Acyclic retinoid, a synthetic retinoid targeting RXR., prevented the recurrence of hepatocellular carcinoma(HCC) in hepatitis C virus-positive patients in a phase II/III clinical trial. This agent also inhibits obesity-related liver tumorigenesis and acts synergistically with valproic acid, GW4064, a FXR ligand, and branched-chain amino acids in suppressing growth in human HCC cells, indicating that "combination chemoprevention" with acyclic retinoid as the key drug has great potential to become an effective strategy for the prevention of liver carcinogenesis.

无环类视黄素是一种靶向RXR的合成性类维生素类动物，在II/III期临床试验中阻止了丙型肝炎病毒阳性患者中肝细胞癌（HCC）的复发。 This agent also inhibits obesity-related liver tumorigenesis and acts synergistically with valproic acid, GW4064, a FXR ligand, and branched-chain amino acids in suppressing growth in human HCC cells, indicating that "combination chemoprevention" with acyclic retinoid as the key drug has great potential to become an effective strategy for the prevention of liver carcinogenesis.

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice

DOI：
10.1016/j.bbrc.2011.05.115
发表时间：
2011-06-24
期刊：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子：
3.1
作者：
Kubota, Masaya;Shimizu, Masahito;Moriwaki, Hisataka
通讯作者：
Moriwaki, Hisataka

Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway

DOI：
10.1038/labinvest.2009.110
发表时间：
2010-01-01
期刊：
LABORATORY INVESTIGATION
影响因子：
5
作者：
Komi, Yusuke;Sogabe, Yukihisa;Kojima, Soichi
通讯作者：
Kojima, Soichi

Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2

DOI：
10.1007/s00432-010-0938-0
发表时间：
2011-05
期刊：
Journal of Cancer Research and Clinical Oncology
影响因子：
3.6
作者：
J. Kitagawa;T. Hara;H. Tsurumi;Soranobu Ninomiya;Kengo Ogawa;Seiji Adachi;N. Kanemura;S. Kasahara;M. Shimizu;H. Moriwaki
通讯作者：
J. Kitagawa;T. Hara;H. Tsurumi;Soranobu Ninomiya;Kengo Ogawa;Seiji Adachi;N. Kanemura;S. Kasahara;M. Shimizu;H. Moriwaki

ワークショップ23-1「Cancer prevention/chemoprevention」Supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver carcinogenesis in obese mice

研讨会23-1“癌症预防/化学预防”补充支链氨基酸可抑制肥胖小鼠二乙基亚硝胺诱导的肝癌发生