Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methylpredonislone and essential fatty acids

基于甲泼尼龙和必需脂肪酸对 P-糖蛋白的表达和功能变化的炎症性肠病的改善

• 批准号: 21590182
• 负责人: HAYASHI Masahiro
• 金额: $ 3万
• 依托单位: Tokyo University of Pharmacy and Life Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590182/
• 关键词: 炎症性腸疾患; methylpredonisolone; P-glycoprotein; 薬物療法; 栄養療法; 必須不飽和脂肪; Dextran Sodium Sulfate; P-glycoproein; 必須不飽和脂肪酸; Dextran sodium sulfate; Methylprednisolone

Linoleic acid(LA) and.-linolenic acid(α-LnA) decrease the absorption of methylpredonisolone(MP) from small intestine in inflammatory bowel disease(IBD) model rats and have delivery effects to large intestine to MP. LA and α-LnA have anti-inflammatory effects and regulatory effects on expression and function of P-glycoprotein(P-gp) in intestinal epithelial cells. It suggests that administration of these essential unsaturated fatty acids not only prevent progress of IBD and also normalize intestinal absorption and disposition of the drug which is a substrate of P-gp in vivo. More experimental information and data are necessary for more efficient administration schedule of drugs in IBD therapy.

亚油酸（LA）和。内酚酸（α-LNA）降低了炎症性肠病（IBD）中小肠中甲基强酮（MP）荒谬的大鼠，并对大肠递送至MP。 LA和α-LNA对肠上皮细胞中P-糖蛋白（P-GP）的表达和功能具有抗炎作用和调节作用。它表明，对这些必需的不饱和脂肪酸的施用不仅可以防止IBD的进展，还可以使肠道吸收和处置归一化，该药物是体内p-gp的底物。对于IBD疗法中更有效的药物给药时间表，需要更多的实验信息和数据。

项目成果

Acylcarnitines as useful absorption enhancer in clinical use

酰基肉碱作为临床应用中有用的吸收促进剂

• 发表时间: 2011
• 作者: N. Doi;M. Tomita;A. Kimura and M. Hayashi
• 通讯作者: A. Kimura and M. Hayashi

Enhancing mechanism of drug absorption by acylcarnitines

酰基肉碱增强药物吸收的机制

• 发表时间: 2012
• 作者: N. Doi;A. Kimura;M. Tomita and M. Hayashi
• 通讯作者: M. Tomita and M. Hayashi

Effect of aminoguanidine on ischemia/reperfusion injury in rat small intestine

氨基胍对大鼠小肠缺血/再灌注损伤的影响

• 发表时间: 2011
• 期刊: Biol.Pharm.Bull.
• 作者: Y.Takizawa;H.Kishimoto;T.Kitazato;M.Tomita;M.Hayashi
• 通讯作者: M.Hayashi

アシルカルニチンの吸収促進作用の腸管部位差

酰基肉碱促进吸收作用的肠道部位差异

• 发表时间: 2011
• 作者: 土井信幸;富田幹雄;木村あおい;林正弘
• 通讯作者: 林正弘

Effects of antioxidants on the ischemia/reperfusion injury in rat

抗氧化剂对大鼠缺血/再灌注损伤的影响

• DOI: 10.1007/s13318-010-0020-y
• 发表时间: 2011
• 期刊: Eur.J.Drug Metab.Pharmacokinet.
• 作者: Y.Takizawa;H.Kishimoto;T.Kitazato;M.Tomita;M.Hayashi
• 通讯作者: M.Hayashi