Induction mechanism of imposex in marine gastropods by retinoids

类维生素A诱导海洋腹足动物强行性的机制

• 批准号: 21590143
• 负责人: NISHIKAWA Jun-ichi
• 金额: $ 2.83万
• 依托单位: Mukogawa Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590143/
• 关键词: 環境化学; レチノイン酸受容体; レチノイド; 核内受容体; インポセックス; イボニシ; 内分泌撹乱物質; レチノイドX受容体

Organotin compounds have been widely used as antifouling pints for ships and fishing nets since the 1960s and have thus released into marine environments. Aquatic invertebrates, particularly marine gastropods, are extremely sensitive to organotin compounds such as tributyltin(TBT) and triphenyltin(TPT). So far, very low-concentartion of TBT or TPT have been shown to induce imposex(superimposition of male genitalia on female) in marine gastropods. Although the inposex induction mechanism has been controversial for many years, we have reported that TBT and TPT are potent and efficacious activators of retinoid X receptor(RXR), and the natural ligand of RXR, 9-cis retinoic acid, induces imposex. However, in vertebrates, all-trans retinoic acid is well-known morphogen important for axial patterning and organ formation in early development. In this study, we analyze the molluscan receptor for all-trans retinoic acid in the view of the evolutionary history of retinoid machinery.

自1960年代以来，有机蛋白化合物已被广泛用作船舶和渔网的防毒品脱，因此已释放到海洋环境中。水生无脊椎动物，尤其是海洋腹足动物，对有机蛋白化合物（例如托物丁基（TBT）和triphenyltin（TPT））极为敏感。到目前为止，已经显示出非常低的TBT或TPT浓度可在海洋腹足类动物中诱导雄性生殖器叠加（雄性生殖器的叠加）。尽管多年来的Inposex诱导机制一直存在争议，但我们报道说TBT和TPT是类维生素类X受体（RXR）的有效和有效的激活剂，RXR的天然配体，9-钙乙酸酯酸的天然配体诱导了Imposex。然而，在脊椎动物中，全反式视黄酸对于早期发育中的轴向图案和器官形成很重要。在这项研究中，我们分析了类球体机械的进化史，分析了全反式视黄酸的软体动物受体。

项目成果

Effect of Lipopolysaccharide on the Xenobiotic-Induced Expression and Activity of Hepatic Cytochrome P450 in Mice

• DOI: 10.1248/bpb.35.473
• 发表时间: 2012-04-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Moriya, Nozomu;Kataoka, Hiromi;Kugawa, Fumihiko
• 通讯作者: Kugawa, Fumihiko

Site-directed mutagenesis of rat thioltransferase : effect of essential cysteine residues for protection against oxidative stress.

大鼠硫醇转移酶的定点诱变：必需半胱氨酸残基对氧化应激的保护作用。

• 发表时间: 2010
• 期刊: J.Biochem.Molecular Toxicology
• 作者: Terada;T.
• 通讯作者: T.

Effect of lipopoly saccharide on the xenobiotic nduced expression and activity of hepatic cytochrome P450 in mice

脂多糖对异生素诱导的小鼠肝细胞色素P450表达和活性的影响

• 发表时间: 2012
• 期刊: Biol. Pharm. Bull
• 作者: Moriya N;Kataoka H;Fujino H;Nishikawa J;Kugawa F
• 通讯作者: Kugawa F

感染症とI型アレルギーマウスにおける肝代謝機能の動態解析

传染病及I型过敏小鼠肝脏代谢功能动态分析

• 发表时间: 2010
• 作者: 川原正博;小山裕也;定金豊;水口貴章,内村浩正,木曽良明,齋藤一樹;森家望
• 通讯作者: 森家望

防災のための備蓄水の安全性評価

防灾储水安全评价

• 发表时间: 2012
• 作者: Miho Sakai;Kenji Yamagishi;Yasuo Suzuki;Hiroaki Tokiwa;片岡裕美
• 通讯作者: 片岡裕美