Mechanisms of Itch

瘙痒的机制

• 批准号: 12670838
• 负责人: TAKAMORI Kenji
• 金额: $ 1.54万
• 依托单位: JUNTENDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670838/
• 关键词: itch; mechanism of itch; nerve fiber; C fiber; opioid peptide; opioid receptor; μ-receptor; κ-receptor; かゆみ; ドライスキン; アトピー性皮膚炎; 表皮内神経線維; C線維; セマフォリン; 老人性皮膚掻痒症; NGF; neurotrophic factor

Itch is classified into 2 types such as peripheral itch and central itch. Peripheral itch is caused by the activation of nerve C fibers which is distributed in the dermoepidermal junction, while central itch is caused by the activation of opioid peptide-opiold receptor system. Clinically itch is grouped by itch which shows effectiveness to antihistamine drugs and itch shows resistance to antihistamine drugs. In this research, we investigated the mechanisms of itch of xerosis, atopic dermatitis and hemodialysis patients which shows resistance to antihistamine drugs. 1)nerve C fibers which penetrated into the subcomear area are activated directly by the outer stimulants such as mechanical, chemical and thermal stimulations in dry skin of zerosis and atopic dermatitis, resulted in itching. 2)In patients with hemodialysis, ti -opioid system indtices itching is superior to ii -opioid system suppress itching. Agonist of κ-opioid receptor suppressed itching of patients with hemodialysis.These findings suggest that agonist of κ-opioid receptor suppress the itching shows resistance against antihistamine drugs.

临床上瘙痒分为外周性瘙痒和中枢性瘙痒两种类型，外周性瘙痒是由分布于真皮表皮交界处的神经C纤维激活引起的，而中枢性瘙痒是由阿片肽-阿片受体系统激活引起的。瘙痒可分为对抗组胺药物有效的瘙痒和对抗组胺药物耐药的瘙痒。在本研究中，我们研究了干燥症、特应性瘙痒的机制。对抗组胺药物有抵抗力的皮炎和血液透析患者 1）皮肤干燥和特应性皮炎的机械、化学和热刺激等外界刺激直接激活深入到粉刺下区域的神经C纤维，导致瘙痒。 2)在血液透析患者中​​，ti-阿片系统抑制瘙痒优于ii-阿片系统激动剂。 κ-阿片受体抑制血液透析患者的瘙痒。这些研究结果表明κ-阿片受体激动剂抑制瘙痒表现出对抗组胺药物的抵抗力。

项目成果

高森 建二: "かゆみと疾患"最新皮膚科学大系. 3. 128-132 (2002)

Kenji Takamori：“瘙痒与疾病”最新皮肤病学。 3. 128-132 (2002)

高森 建二: "かゆみの機序"最新皮膚科学大系. 3. 120-127 (2002)

Kenji Takamori：“瘙痒的机制”最新皮肤病学。 3. 120-127 (2002)

高森 建二: "かゆみと疾患"最新皮膚科学大系. 3. 128-132 (2002)

Kenji Takamori：“瘙痒与疾病”最新皮肤病学。 3. 128-132 (2002)

高森 建二: "オピオイドペプチドを標的とした痒みの治療"臨床皮膚科. 56. 145-147 (2002)

Kenji Takamori：“针对阿片肽的瘙痒治疗”《临床皮肤病学》56. 145-147 (2002)。

高森建二: "最新アトピー性皮膚炎診療マニュアル-かゆみ対策"Monthly Book Derma. 54. 54-59 (2001)

Kenji Takamori：《最新特应性皮炎治疗手册-瘙痒对策》月刊 Derma 54. 54-59 (2001)