Highly Efficient Excess Electron Transfer in Precisely Designed DNA Architectures

精确设计的 DNA 架构中高效的过量电子转移

• 批准号: 20750009
• 负责人: ITO Takeo
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20750009/
• 关键词: 生物物理化学・DNA内電子移動; 核酸; 時間分解分光測定; 核酸塩基損傷; 電子移動; アプタマー

Effects of DNA structure on the DNA-mediated electron transfer efficiency were quantitatively investigated using DNA containing novel photo-induced electron donors. It was suggested that local structural changes and electron affinities of DNA sequences as well as redox properties of the electron donors highly affect the electron transfer efficiency.

DNA结构对DNA介导的电子转移效率的影响，使用含有新型光诱导的电子供体的DNA进行了定量研究。有人提出，DNA序列的局部结构变化和电子亲和力以及电子供体的氧化还原特性高度影响电子转移效率。

项目成果

Photoelectrochemical identification of 5-methylcytosine modification in DNA : combination of photosensitization and enzvmatic cleavage

DNA 中 5-甲基胞嘧啶修饰的光电化学鉴定：光敏化和酶裂解的结合

• 发表时间: 2009
• 作者: Takeo Ito;Aiko Hayashi;Tsukasa Uchida;Tanabe Kazuhito;Hisatsugu Yamada;Sei-ichi Nishimoto;佐甲徳栄;Takeo Ito;佐甲徳栄;Hisatsugu Yamada
• 通讯作者: Hisatsugu Yamada

Efficient photooxidative strand cleavage at 5-methylcytosine in DNA by sensitization with 9.10-anthraquinone-tethered oligonuclentides

通过 9.10-蒽醌束缚寡核苷酸的敏化，对 DNA 中的 5-甲基胞嘧啶进行有效的光氧化链切割

• 发表时间: 2009
• 期刊: Nucleic Acids Symposium Series VOL.53
• 作者: Hisatsugu Yamada;et al.
• 通讯作者: et al.

Photoinduced electro transfer reaction in diaminostilbene- tethered DNA duplexes

二氨基芪束缚 DNA 双链体中的光诱导电转移反应

• 发表时间: 2009
• 作者: Takeo Ito;Aiko Hayashi;Tsukasa Uchida;Tanabe Kazuhito;Hisatsugu Yamada;Sei-ichi Nishimoto
• 通讯作者: Sei-ichi Nishimoto

Photoinduced electron transfer reaction in diaminostilbene-tethered DNA duplexes

二氨基芪束缚 DNA 双链体中的光诱导电子转移反应

• 发表时间: 2009
• 期刊: Nucleic Acids Symposium Series VOL.53
• 作者: Takeo Ito;et al.
• 通讯作者: et al.

Reductive electron transfer in DNA (1) : Implications for radiation-induced reductive DNA damage

DNA 中的还原性电子转移 (1)：辐射诱导的还原性 DNA 损伤的影响

• 发表时间: 2008
• 作者: 飯島隆広;西村勝之;山田和彦;松本剛昭;Takeo Ito
• 通讯作者: Takeo Ito