The mirror neuron improve dysphagia? : Evaluation by the multi modality for functional brain imaging

镜像神经元改善吞咽困难？

基本信息

批准号：
20592469
负责人：
WATANABE Yutaka
金额：
$ 2.91万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

项目摘要

Purpose : Mirror neurons fire when a particular action is performed and when the animal observes the same action being performed by another individual. We have demonstrated the activity of mirror neurons during swallowing-related visual stimulation, and investigated the establishment of a new form of rehabilitation. In addition, to examine clinical application of this new rehabilitation, we examined fact-finding about an obstacle of the dietary behavior of the Alzheimer's disease (AD) patients whom conventional rehabilitation had difficulty with.Methods : Subjects were 15 healthy individuals. Brain activity during the presentation of swallowing movements was measured using 3T-fMRI and MEG. The experimental method consisted of showing 16 types of stimulus video to subjects, comprising general videos and fluoroscopic videos. In MEG study, swallowing-related stimuli comprised an animated image of the left profile of a person swallowing water with laryngeal elevation as a visual swallowing … More trigger stimulus, and a swallowing sound as an auditory swallowing trigger stimulus. We measured the brain signal by 3T-fMRI and MEG and analyzed.In fact-finding survey of the diet behavior of the AD patients, The enrolled AD patients, totaled 150 patients, who were residents of institutions or group homes. The patients underwent an eating behavior examination, cognitive assessment, neurological examination, and vital function tests. The eating behavior examination consisted of observation of the patients at mealtime. Items assessed eating behavior included the number of feeding cycles, stopping of eating or agitation, and dysfunction.Results : Activity in mirror neuron areas was observed during water swallowing, fluoroscopic video. Activity in mirror neuron areas was left-hemisphere-dominant during the presentation of WXL and right-hemisphere-dominant during the presentation of CXL. With animation stimuli (animation stimulus, animation+swallowing sound stimuli, animation+artificial sound stimuli), activation in mirror neuron areas, corresponding to mirror neurons, was observed between 620 and 720 ms before the trigger.In fact-finding survey of the diet behavior of the AD patients, Logistic regression analysis performed to identify factors with a significant affect on decreased independence in eating were difficulty in beginning a meal, presence of dysphagia signs, and the severity of dementia.Conclusion : Evaluation by the multi modality for functional brain imaging, I accepted activity in the mirror neuron of the deglutition. In addition, that it was necessary to promote adjustment of the meal environment that promoted a meal start to maintain an independence feeding and a meal start was suggested by fact-finding of the dietary behavior of the AD patient. The possibility that could improve a problem of the appetite of the AD patients that it had been assumed that I was difficult till now by performing the appetite support that I used a mirror neuron system for was suggested by this. Less

目的：当执行特定动作时，镜像神经元以及动物观察到另一个人执行相同的动作时。我们已经证明了吞咽相关的视觉刺激期间镜像神经元的活性，并研究了一种新的康复形式。此外，为了检查这种新的康复的临床应用，我们研究了关于常规康复困难的阿尔茨海默氏病（AD）患者饮食行为（AD）患者的障碍的事实。使用3T-FMRI和MEG测量吞咽运动期间的大脑活动。实验方法包括向主题显示16种类型的刺激视频，完成一般视频和荧光镜视频。在MEG的研究中，与吞咽相关的刺激片完成了一个人的左侧轮廓的动画图像，其中一个人吞咽水，喉头高度作为视觉吞咽……更多的触发刺激，以及作为听觉吞咽触发触发刺激的吞咽声音。我们通过3T-FMRI和MEG测量了大脑信号，并分析了AD患者的饮食行为，招募的AD患者，总计150名患者，是机构或集体住宅的居民。患者进行了饮食行为检查，认知评估，神经系统检查和重要功能测试。饮食行为检查包括在进餐时观察患者。评估的饮食行为的项目包括喂食周期的数量，停止饮食或搅动以及功能障碍。反应：在吞咽，荧光镜视频中观察到镜像神经元区域中的活动。在介绍CXL期间，在WXL和右半球占主导地位时，镜像神经元区域中的活性是左眼的主导性。 With animation stimulus (animation stimulus, animation+swallowing sound stimulus, animation+artificial sound stimulus), activation in mirror neurons, corresponding to mirror neurons, was observed between 620 and 720 ms before the trigger.In fact-finding survey of the diet behavior of the AD patients, Logistic regression analysis performed to identify factors with a significant affect on decreased in eating were difficult in Beginning a meal, presence of dysphagia signs, and痴呆症的严重性。结论：通过多模态对功能性脑成像进行评估，我接受了脱水的镜像神经元中的活性。此外，有必要促进促进进餐的餐食环境的调整，以维持独立性喂养，并通过对广告患者的饮食行为进行事实调查来提出饮食开始。可以通过执行我使用镜像神经元系统的食欲支持来改善AD患者食欲的问题的可能性。较少的