The mirror neuron improve dysphagia? : Evaluation by the multi modality for functional brain imaging

镜像神经元改善吞咽困难？

基本信息

批准号：
20592469
负责人：
WATANABE Yutaka
金额：
$ 2.91万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

项目摘要

Purpose : Mirror neurons fire when a particular action is performed and when the animal observes the same action being performed by another individual. We have demonstrated the activity of mirror neurons during swallowing-related visual stimulation, and investigated the establishment of a new form of rehabilitation. In addition, to examine clinical application of this new rehabilitation, we examined fact-finding about an obstacle of the dietary behavior of the Alzheimer's disease (AD) patients whom conventional rehabilitation had difficulty with.Methods : Subjects were 15 healthy individuals. Brain activity during the presentation of swallowing movements was measured using 3T-fMRI and MEG. The experimental method consisted of showing 16 types of stimulus video to subjects, comprising general videos and fluoroscopic videos. In MEG study, swallowing-related stimuli comprised an animated image of the left profile of a person swallowing water with laryngeal elevation as a visual swallowing … More trigger stimulus, and a swallowing sound as an auditory swallowing trigger stimulus. We measured the brain signal by 3T-fMRI and MEG and analyzed.In fact-finding survey of the diet behavior of the AD patients, The enrolled AD patients, totaled 150 patients, who were residents of institutions or group homes. The patients underwent an eating behavior examination, cognitive assessment, neurological examination, and vital function tests. The eating behavior examination consisted of observation of the patients at mealtime. Items assessed eating behavior included the number of feeding cycles, stopping of eating or agitation, and dysfunction.Results : Activity in mirror neuron areas was observed during water swallowing, fluoroscopic video. Activity in mirror neuron areas was left-hemisphere-dominant during the presentation of WXL and right-hemisphere-dominant during the presentation of CXL. With animation stimuli (animation stimulus, animation+swallowing sound stimuli, animation+artificial sound stimuli), activation in mirror neuron areas, corresponding to mirror neurons, was observed between 620 and 720 ms before the trigger.In fact-finding survey of the diet behavior of the AD patients, Logistic regression analysis performed to identify factors with a significant affect on decreased independence in eating were difficulty in beginning a meal, presence of dysphagia signs, and the severity of dementia.Conclusion : Evaluation by the multi modality for functional brain imaging, I accepted activity in the mirror neuron of the deglutition. In addition, that it was necessary to promote adjustment of the meal environment that promoted a meal start to maintain an independence feeding and a meal start was suggested by fact-finding of the dietary behavior of the AD patient. The possibility that could improve a problem of the appetite of the AD patients that it had been assumed that I was difficult till now by performing the appetite support that I used a mirror neuron system for was suggested by this. Less

目的：当动物执行特定动作时以及当动物观察到另一个个体执行相同动作时，镜像神经元会放电。我们已经证明了镜像神经元在吞咽相关视觉刺激期间的活动，并研究了一种新的康复形式的建立。此外，为了检验这种新康复疗法的临床应用，我们对传统康复疗法难以解决的阿尔茨海默病（AD）患者的饮食行为障碍进行了事实调查。方法：受试者为 15 名健康个体。的介绍使用 3T-fMRI 和 MEG 测量吞咽运动，实验方法包括向受试者展示 16 种刺激视频，包括普通视频和透视视频。在 MEG 研究中，与吞咽相关的刺激包括左侧轮廓的动画图像。我们通过 3T-fMRI 和 MEG 测量了人吞咽水的视觉吞咽触发刺激，以及吞咽声音作为听觉吞咽触发刺激。对AD患者饮食行为的实况调查，纳入AD患者共150名，均为机构或团体之家的居民，患者接受了饮食行为检查、认知评估、神经系统检查和生命功能测试。饮食行为检查包括进食时观察患者的饮食行为，评估项目包括进食周期数、停止进食或躁动以及功能障碍。结果：观察吞水过程中镜像神经元区域的活动，透视活动。在镜像神经元区域在 WXL 呈现期间以左半球为主，在 CXL 呈现期间以右半球为主。通过动画刺激（动画刺激、动画+吞咽声音刺激、动画+人工声音刺激），镜像神经元被激活。在触发前 620 至 720 毫秒之间观察到对应于镜像神经元的区域。在对 AD 患者饮食行为的事实调查中，进行 Logistic 回归分析以识别具有显着影响的因素。进食独立性下降的影响包括开始进餐困难、吞咽困难症状以及痴呆的严重程度。结论：通过功能性脑成像的多模态评估，我接受了吞咽镜像神经元的活动。通过对AD患者的饮食行为的事实调查发现，有必要促进促进进餐的进餐环境的调整，以维持独立进食和进餐，从而改善食欲问题。的 AD 患者中，人们一直认为到目前为止，我很难通过使用镜像神经元系统来进行食欲支持，这是Less建议的。