Development of a Periodontal Disease Screening System Using Biomarkers in Saliva

利用唾液中的生物标志物开发牙周病筛查系统

• 批准号: 20592461
• 负责人: SOH Inho
• 金额: $ 3万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592461/
• 关键词: 歯周病; ストレス評価; 唾液検査; QOL評価; ホルモン

Recent studies have found a positive relationship between periodontitis and the hormones cortisol and dehydroepiandrosterone (DHEA). We investigated the associations between periodontitis and the cortisol and DHEA levels in elderly never-smokers and smokers. The cortisol and DHEA levels in saliva were determined, together with the probing depth (PD) and clinical attachment loss (CAL), in 171 subjects (85 males, 86 females). Smoking affected the cortisol and DHEA levels, which were significantly associated with severe PD and CAL in never-smokers. According to the ROC analysis, the respective cutoff values for cortisol and DHEA that gave the optimal sensitivity and specificity for detecting severe periodontitis were 2.06ng/mL and 60.24pg/mL for PD and 2.12ng/mL and 61.78pg/mL for CAL. An assessment of hormone levels may be a useful screening method for periodontitis, although its utility is limited to never-smokers.

最近的研究发现，牙周炎与荷尔蒙皮质醇和脱氢表甲酮（DHEA）之间存在正相关关系。我们研究了老年从未吸烟者和吸烟者的牙周炎与皮质醇和DHEA水平之间的关联。在171名受试者（85名男性，86名女性）中，确定了唾液中的皮质醇和DHEA水平，以及探测深度（PD）和临床附着损失（CAL）。吸烟影响了皮质醇和DHEA水平，这些水平与从未吸烟者中的严重PD和CAL显着相关。根据ROC分析，在检测严重牙周炎的最佳敏感性和特异性的皮质醇和DHEA的截止值为2.06ng/ml和PD的60.24pg/ml，Cal的2.12ng/mL和61.78pg/ml。对激素水平的评估可能是牙周炎的有用筛查方法，尽管其效用仅限于从未吸烟的人。

项目成果

Neutral Endopeptidase and Endothelin-converting Enzyme in Human Buccal Mucosal Epithelium.

人颊粘膜上皮中的中性内肽酶和内皮素转化酶。

• 发表时间: 2010
• 作者: Kinoshita;N.;Awano;S.;Yoshida;A.;Soh;I.;Mineoka;T.;Ansai;T.
• 通讯作者: T.

口腔乾燥症の病態と唾液中コルチゾルおよびDHEAとの関係

口干症病理与唾液皮质醇、DHEA的关系

• 发表时间: 2008
• 作者: 安細敏弘;茂山千英子;邵仁浩(他5名3番目)
• 通讯作者: 邵仁浩(他5名3番目)

Serum albumin levels as an independent predictor of 4-year mortality in a community-dwelling 80-year-old population.

血清白蛋白水平是社区居住 80 岁人群 4 年死亡率的独立预测因子。

• 发表时间: 2010
• 期刊: Aging Clinical and Experimental Research
• 影响因子: 4
• 作者: Takata Y;Ansai T;et al.
• 通讯作者: et al.

Association of cortisol and dehydroepiandrosterone sulfate levels in serum with periodontal status in older Japanese adults.

日本老年人血清中皮质醇和硫酸脱氢表雄酮水平与牙周状况的关系。

• 发表时间: 2008
• 期刊: J. Clin. Periodontol。 35
• 作者: Ishisaka;A.;その;他
• 通讯作者: 他

Relationship between chewing ability and high-level functional capacity in an 80-year-old population.

80 岁人群咀嚼能力与高级功能能力之间的关系。

• 发表时间: 2008
• 期刊: Gerodontology 25
• 作者: Takata;Y.;Ansai;T.;Soh;I;et al.
• 通讯作者: et al.