Molecular mechanism of cyto-differentiation of proliferating bone resorping lesions

增殖性骨吸收病变细胞分化的分子机制

• 批准号: 20592349
• 负责人: KAWAKAMI Toshiyuki
• 金额: $ 2.91万
• 依托单位: Matsumoto Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592349/
• 关键词: 口腔外科学一般; 歯原性腫瘍; エナメル上皮腫; 石灰化嚢胞性歯原性腫瘍; 石灰化歯原性腫瘍; 軟骨肉腫; Notch; Jagged; Delta; ameloblastoma; Notch signaling; 細胞分化; 細胞増殖; 免疫組織化学; 腫瘍の組織型; 骨吸収; 顎骨; 腫瘍; 歯; シグナリング

We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In summary, the results showed that these morphogenesis regulation Notch and related factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratio was frequently positive, and was nearly the same between the varied histopathological, cytological patterns; however, the less-differentiated cells were slightly fewer in number that that of well-differentiated cells.

我们在典型的固体/多细胞蛋白细胞瘤的串行大病例中检查了Notch信号分子Notch1和Jagged1。总而言之，结果表明，这些形态发生调节缺口和相关因素与熟母细胞瘤肿瘤细胞的细胞学分化密切相关。缺口和锯齿状的阳性比率通常是阳性的，并且在各种组织病理学，细胞学模式之间几乎相同。但是，差异较少的细胞的数量略低于分化良好的细胞的数量。

项目成果

Heparanase and its related molecules in odontogenic tumors

• DOI: 10.3353/omp.13.81
• 发表时间: 2009
• 期刊: Oral Medicine & Pathology
• 作者: H. Nagatsuka;Katase Naoki;Han Phuu Pwint;H. Tsujigiwa;S. Huat;M. Nakajima;Y. Naomoto;R. Tamamura;T. Kawakami;G. Mehmet

Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype

• DOI: 10.1016/j.tripleo.2010.03.009
• 发表时间: 2010-08-01
• 期刊: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
• 作者: Siar, Chong Huat;Nagatsuka, Hitoshi;Kawakami, Toshiyuki
• 通讯作者: Kawakami, Toshiyuki

Immunohistchemical expression of Notch signaling in calcifying cystic odontogenic tumor

Notch信号在牙源性钙化囊性肿瘤中的免疫组织化学表达

• 发表时间: 2010
• 作者: Kawakami T;Siar CH;Nakano K;Tomida M;Matsuura S;Tsujigiwa H;Nagatsuka H
• 通讯作者: Nagatsuka H

Notch receptors and their ligands in ameloblastomas

成釉细胞瘤中的Notch受体及其配体

• 发表时间: 2009
• 作者: Siar CH;Kawakami T;Nakano K;Nagatsuka H;Ng KH
• 通讯作者: Ng KH

Ameloblastomaとameloblastic carcinomaにおけるNotchの発現

Notch在成釉细胞瘤和成釉细胞癌中的表达

• 发表时间: 2008
• 作者: Tsujigiwa H;Nagatsuka H;Han PP;Gunduz M;Siar CH;Oida S and Nagai N;Shimizu T;Kawakami T;Inoue M;Tsujigiwa H;Nagatsuka H;Tsujigiwa H;Gul San Ara Sathi;Silvia Borkosky;Mahmoud Al Sheikh All;Lefeuvre Mathieu;Silvia Susana Borkosky;Gul San Ara Sathi;Mahmoud Al Sheikh Ali;M. Gunduz;R. Rivera;長塚仁;片瀬直樹;中野敬介
• 通讯作者: 中野敬介