The role of water channel of aquaporins and water pump of Na-K-2Cl co-transporter on the water homeostasis of the inner ear.

水通道蛋白的水通道和Na-K-2Cl协同转运蛋白的水泵对内耳水稳态的作用。

• 批准号: 20591987
• 负责人: TAKEDA Taizo
• 金额: $ 3.08万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591987/
• 关键词: aquaporin; イオン共輸送体; 血管条; 内リンパ嚢; vasopressin; 水チャネル; NKCC1; NKCC2; stria vascularis; endolymphatic sac; bumetanide; 内耳水代謝

The expressions of many subtypes of aquaporins (AQP) including AQP-2, vasopressin type 2 receptor, and NKCC1 were molecular biologically and immunohistochemically evaluated. Since the application of vasopressin, bumetanide, and OPC-31260 exerted the morphological influence on the intrastrial space, AQP2-vasopressin mediated water transport and water flow through the Na-K-Cl co-transporter might work actively in the inner ear fluid homeostasis.

对水通道蛋白 (AQP) 的许多亚型（包括 AQP-2、加压素 2 型受体和 NKCC1）的表达进行了分子生物学和免疫组织化学评估。由于加压素、布美他尼和 OPC-31260 的应用对心房空间产生形态影响，因此 AQP2-加压素介导的水转运和通过 Na-K-Cl 协同转运蛋白的水流可能在内耳液体稳态中发挥积极作用。

项目成果

Expression and immunolocalization of aquaporin-6 (Aqp6) in the rat inner ear

• DOI: 10.1080/00016480701765691
• 发表时间: 2008-01-01
• 期刊: ACTA OTO-LARYNGOLOGICA
• 影响因子: 1.4
• 作者: Taguchi, Daizo;Takeda, Taizo;Kitano, Hiroya
• 通讯作者: Kitano, Hiroya

Expression of aquaporins and vasopressin type 2 receptor in the stria vascularis of the cochlea

• DOI: 10.1016/j.heares.2009.09.011
• 发表时间: 2010-02
• 期刊: Hearing Research
• 影响因子: 2.8
• 作者: R. Nishioka;T. Takeda;A. Kakigi;Teruhiko Okada;Shinji Takebayashi;Daizo Taguchi;M. Nishimura;Masamitsu Hyodo

Expression of aquaporin1, 2, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac

人内淋巴囊中水通道蛋白 1、2、3 和 4、NKCC1 和 NKCC2 的表达

• 发表时间: 2008
• 作者: Kakigi A;Nishimura M;Takeda T;Taguchi D;Nishioka R
• 通讯作者: Nishioka R

Bumetanide-Induced Enlargement of the Rat Intrastrial Space and Effects of a Vasopressin Type 2 Antagonist

布美他尼诱导的大鼠颅内空间扩大和 2 型加压素拮抗剂的作用

• 发表时间: 2010
• 期刊: ORL J Otorhinolaryngol Relat Spec
• 作者: Nishimura M;Kakigi A;Takeda T;Okada T;Doi K
• 通讯作者: Doi K

Expression of aquaporin1, 3, and 4, NKCC1, and NKCC2 in the human endolymphatic sac

• DOI: 10.1016/j.anl.2008.04.012
• 发表时间: 2009-04-01
• 期刊: AURIS NASUS LARYNX
• 影响因子: 1.7
• 作者: Kakigi, Akinobu;Nishimura, Masahiko;Nishioka, Rie
• 通讯作者: Nishioka, Rie