Examination of respiratory status and diaphragmatic function in critically ill patients with mechanical ventilation

危重机械通气患者呼吸状态及膈肌功能检查

• 批准号: 20591828
• 负责人: UCHIYAMA Akinori
• 金额: $ 3.08万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591828/
• 关键词: 周術期管理学; 臨床; 生理学; 集中治療; 人工呼吸; 横隔膜; 気管チューブ; 調節呼吸; 自発呼吸テスト; 呼吸仕事量; 腎不全; NGAL; 鎮静薬; 呼気抵抗; 呼吸不全; 人工呼吸モード

Respiratory muscle function largely affects prognosis of critically ill patients received mechanical ventilation. We examined methods of assessing tension of respiratory muscle and factors related to respiratory muscle function during mechanical ventilation. Patient's level of consciousness affected tensions by voluntary efforts. It was difficult to determine the site of stimulation in ICU patients in percutaneous stimulation for phrenic nerve. Effects of sedatives and mode of mechanical ventilation on assessment of respiratory muscle function were studied. Imposed expiratory work of breathing during mechanical ventilation and the relationship between renal failure and respiratory failure were also examined. The results were considered to be useful respiratory care to preserve respiratory muscle function.

呼吸道肌肉功能在很大程度上影响了重症患者的预后接受机械通气。我们检查了评估呼吸肌肉张力以及在机械通气过程中与呼吸肌功能相关的因素的方法。患者的意识水平受自愿努力影响的紧张局势。在经皮神经的经皮刺激中，很难确定ICU患者的刺激部位。研究了镇静剂和机械通气模式对呼吸肌功能评估的影响。还检查了机械通气过程中呼吸的呼气工作以及肾衰竭与呼吸衰竭之间的关系。结果被认为是保留呼吸肌功能的有用呼吸护理。

项目成果

An Expiratory Assist During Spontaneous Breathing Can Compensate for Endotracheal Tube Resistance

自主呼吸期间的呼气辅助可以补偿气管插管阻力

• 发表时间: 2009
• 期刊: Anesthesia and Analgesia 109
• 作者: Akinori Uchiyama;Cheng Chang;Shinya Suzuki;Takashi Mashimo;Yuji Fujino
• 通讯作者: Yuji Fujino

Estimation of imposed expiratory work of breathing by endotracheal tube and ventilator during mechanical ventilation

机械通气时气管插管和呼吸机施加的呼吸呼气功的估计

• 发表时间: 2011
• 作者: Akinori Uchiyama;Yoshida Takeshi;Hidenori Yamanaka;Takashi Mashimo;Yuji Fujino
• 通讯作者: Yuji Fujino

人工呼吸中に負荷される呼気仕事量についての検討

人工呼吸时呼气功负荷的考虑

• 发表时间: 2011
• 作者: 内山昭則;藤野裕士
• 通讯作者: 藤野裕士

A Comparison of the Effects on Respiratory Carbon Dioxide Response, Arterial Blood Pressure, and Heart Rate of Dexmedetomidine, Propofol, and Midazolam in Sevoflurane-Anesthetized Rabbits

• DOI: 10.1213/ane.0b013e3181a2ad5f
• 发表时间: 2009-07-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Chang, Cheng;Uchiyama, Akinori;Fujino, Yuji
• 通讯作者: Fujino, Yuji

急性腎障害(AKI)発症後の血漿NGAL値の検討

急性肾损伤 (AKI) 发作后血浆 NGAL 水平的检查

• 发表时间: 2011
• 作者: 井口直也;内山昭則;藤野裕士
• 通讯作者: 藤野裕士