Basic research for evaluating the donor lung mechanical properties using FOT (Forced Oscillation Technique)

使用 FOT（强制振荡技术）评估供体肺机械特性的基础研究

• 批准号: 20591667
• 负责人: SAKAI Hiroaki
• 金额: $ 2.58万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591667/
• 关键词: FOT; lung mechanical property; 強制オッシレーション法; 肺移植; 急性拒絶反応; 慢性拒絶反応; 肺保存; 冷保存; ラット肺移植; Impulse Oscillation System; FOT; lung mechanical property; 強制オッシレーション法; 肺移植; 急性拒絶反応; 慢性拒絶反応; 肺保存; 冷保存; ラット肺移植; Impulse Oscillation System

The forced oscillation technique (FOT) was a method to characterize respiratory impedance. Recently, FOT has been applied in both human subjects and animal models of lung disease. The main advantages of FOT are its noninvasiveness with minimal subject cooperation, and its potential ability to reflect the magnitude and distribution of airway and tissue diseases from frequency-dependent features of parameters. We applied this method to evaluate the mechanical properties of the cold storage rat lung and reported the results. We also reported case that the possibility of early detection of acute rejection after lung transplantation using FOT in humans. However the relationship between histopathology and respiratory impedance spectra has not been studied. In the next step we are planning to evaluate the sensitivity and specificity of the lung impedance (ZL) parameters, in identifying the relationship between histopathological AR grade and lung mechanics in a rat lung transplantation model. We considered that inferring structure from function is described the goal of medical diagnosis.

强制振荡技术（FOT）是一种表征呼吸阻抗的方法。最近，FOT已应用于人类受试者和肺部疾病的动物模型。 FOT的主要优点是其与最小的主题合作的无创性，以及其反映来自参数频率依赖性特征的气道和组织疾病的大小和分布的潜在能力。我们应用了这种方法来评估冷储存大鼠肺的机械性能并报告了结果。我们还报告了案例，即使用FOT在人类中使用FOT早期发现急性排斥反应的可能性。但是，尚未研究组织病理学和呼吸阻抗光谱之间的关系。在下一步中，我们计划评估肺阻抗（ZL）参数的敏感性和特异性，以确定大鼠肺移植模型中组织病理学AR等级与肺部力学之间的关系。我们认为，从功能中推断结构是医学诊断的目的。