Paclitaxel combined with hyarulonic acid as the new drug for peritoneal dissemination of gastric cancer.

紫杉醇联合透明质酸作为治疗腹膜播散性胃癌的新药。

• 批准号: 20591563
• 负责人: KITAYAMA Joji
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591563/
• 关键词: 腹膜播種; 腹腔内化学療法; パクリタキセル; シスプラチン; NASHA; 腹腔内投与; PMB30W; 胃癌; ヒアルロン酸

Intraperitoneal chemotherapy has been shown to be clinically useful for peritoneal matastais. In this study, we hypothesized that high molecular weight Hyarulonic Acid may retain the intraperitoneally administrated anticancer drugs in abdominal cavity and enhance the anti-tumor effects, and examined the effect of Non-Animal Stabilized Hyarulonic Acid (NASHA) (Q-Med Sweden). In fact, the addition of 5% NASHA suppressed the development of peritoneal nodules of MKN45 inplanted in nude mice significantly greater than paclitaxel or cisplatin alone. NASHA also increased the volume of fluid recovered from the mice. Intraperitoneal administration paclitaxel or cisplatin combined with NASHA can be a hopeful strategy as the treatment of peritoneal dissemination.

腹膜内化学疗法已被证明对腹膜马tast术在临床上有用。在这项研究中，我们假设高分子量透明质酸可能会在腹腔中保留腹膜内的抗癌药物并增强抗肿瘤作用，并检查了非动物稳定的透明质酸（NASHA）（NASHA）（Q-MED瑞典）的作用。实际上，添加5％的Nasha抑制了在裸鼠中植入的MKN45的腹膜结节的发育明显大于紫杉醇或顺铂。 Nasha还增加了从小鼠中回收的液体的体积。腹膜内给药紫杉醇或顺铂与Nasha结合使用，可以作为腹膜传播的一种充满希望的策略。

项目成果

Intra-peritoneal adminlstration of paditaxel with non-animal stabilized hyaluronic acid as aehicle-a new strategy against perltoneal dissemination of gastric cancer.

非动物稳定透明质酸腹腔注射紫杉醇——对抗胃癌腹膜播散的新策略。

• 发表时间: 2008
• 期刊: Cancer Letter 272
• 作者: Tsuchiya S;Sato F;Shimada Y;Tanaka E;Tsujimoto G;et al.;Yamada J et al
• 通讯作者: Yamada J et al

Phase II study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer with peritoneal metastasis.

• DOI: 10.1200/jco.2009.27.15_suppl.4542
• 发表时间: 2009-05
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: H. Ishigami;J. Kitayama;S. Kaisaki;A. Hidemura;M. Kato;K. Otani;T. Kamei;Daisuke Soma;H. Miyato;H. Yamashita;H. Nagawa

Spatial distribution of intraperitoneally administrated paclitaxel nanoparticles solubilized with poly (2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) in peritoneal metastatic nodules

• DOI: 10.1111/j.1349-7006.2010.01747.x
• 发表时间: 2011-01-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Kamei, Takao;Kitayama, Joji;Nagawa, Hirokazu
• 通讯作者: Nagawa, Hirokazu

スキルス胃癌に対するPaclitaxel+ヒアルロン酸(NASHA)腹腔内投与の有用性

腹腔注射紫杉醇+透明质酸（NASHA）治疗硬质胃癌的有效性

• 发表时间: 2008
• 作者: 紅林淳一;他;北由丈二他
• 通讯作者: 北由丈二他

スキルス胃癌に対するPaclitaxel+ヒアルロン酸(NASHA)腹腔内投与の有用性について

关于腹腔注射紫杉醇+透明质酸（NASHA）治疗硬质胃癌的有效性

• 发表时间: 2009
• 期刊: 癌の臨床 55巻1号
• 作者: Sato F;Tsuchiya S;Meltzer SJ;清水一治;北山丈二,山田純,名川弘一
• 通讯作者: 北山丈二,山田純,名川弘一