The role of the mitochondrial targeting signal in the function of steroidogenic acute regulatory protein revealed by BAC transgenesis in vivo

BAC体内转基因揭示线粒体靶向信号在类固醇生成急性调节蛋白功能中的作用

• 批准号: 20591231
• 负责人: ISHII Tomohiro
• 金额: $ 2.91万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591231/
• 关键词: steroidogenic acute regulatory protein; ステロイドホルモン; 細菌人工染色体(BAC); トランスジェニックマウス; ミトコンドリア標的シグナル; 細菌人工染色体

The present study clarified the mechanism of steroidogenic acute regulatory protein (StAR) that transfers cholesterol from the outer to the inner mitochondrial membrane in the first step of acute steroidogenesis. It demonstrated the important role of mitochondrial entry of StAR by its mitochondrial targeting signal on the function of the StAR in vivo.

本研究阐明了类固醇生成急性调节蛋白（StAR）的机制，该蛋白在急性类固醇生成的第一步中将胆固醇从线粒体外膜转移到内膜。通过其线粒体靶向信号对StAR体内功能的影响，证明了StAR进入线粒体的重要作用。

项目成果

Complex role of the mitochondrial targeting signal in the function of steroidogenic acute regulatory protein revealed by bacterial artificial chromosome transgenesis in vivo.

• DOI: 10.1210/me.2007-0493
• 发表时间: 2008-04
• 期刊: Molecular endocrinology
• 作者: G. Sasaki;T. Ishii;P. Jeyasuria;Y. Jo;Assaf Bahat;J. Orly;T. Hasegawa;K. Parker

Steroidogenic acute regulatory protein のin vivo における機能解析

类固醇生成急性调节蛋白的体内功能分析

• 发表时间: 2009
• 作者: 久保和泰;山本幸代;川越倫子;後藤元秀;荒木俊介;土橋一重;楠原浩一;石井智弘
• 通讯作者: 石井智弘