Abnormal modulation for spinal neural system in central motor disorders and its reconstruction during functional recovery

中枢运动障碍中脊髓神经系统的异常调节及其功能恢复过程中的重建

• 批准号: 20591021
• 负责人: MORITA Hiroshi
• 金额: $ 3.08万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591021/
• 关键词: 臨床神経生理学; 運動調節; 脊髄抑制機構; 経頭蓋磁気刺激; 運動準備; パーキンソン病; 痙縮; H反射; 脊髄反射

To investigate inadequate supraspinal modulation and reorganization during functional recovery of spinal neural systems in spasticity and parkinsonism, we tried to set up special experimental system to investigate neural activity before onset of voluntary contraction. Additionally we investigated the safety of transcranial magnetic stimulation(TMS) in patients deep brain stimulation(DBS) system implanted using model system. We concluded that TMS in patients with DBS implanted was safe when we took care some technical procedures.

为了研究痉挛和帕金森病中脊髓神经系统功能恢复过程中脊髓上调制和重组的不足，我们尝试建立特殊的实验系统来研究随意收缩开始前的神经活动。此外，我们还研究了使用模型系统植入患者深部脑刺激（DBS）系统的经颅磁刺激（TMS）的安全性。我们得出的结论是，当我们采取一些技术程序时，植入 DBS 的患者的 TMS 是安全的。

项目成果

The safety of transcranial magnetic stimulation with deep brain stimulation instruments

深部脑刺激仪经颅磁刺激的安全性

• 发表时间: 2010
• 期刊: Parkinsonism and Related Disorders
• 影响因子: 4.1
• 作者: Shimojima Y;Morita H;Nishikawa N;Kodaira M;Hashimoto T;Ikeda SI
• 通讯作者: Ikeda SI

Exome Sequencing Reveals a Homozygous SYT14 Mutation in Adult-Onset, Autosomal-Recessive Spinocerebellar Ataxia with Psychomotor Retardation

• DOI: 10.1016/j.ajhg.2011.07.012
• 发表时间: 2011-08-12
• 期刊: AMERICAN JOURNAL OF HUMAN GENETICS
• 影响因子: 9.8
• 作者: Doi, Hiroshi;Yoshida, Kunihiro;Matsumoto, Naomichi
• 通讯作者: Matsumoto, Naomichi

The safety of transcranial magnetic stimulation with deep brain stimulation instruments.

深部脑刺激仪器经颅磁刺激的安全性。

• 发表时间: 2010
• 期刊: Parkinsonism and Related Disorders 16
• 作者: Shimojima Y;Morita H;Nishikawa N;Kodaira M;Hashimoto T;Ikeda SI.
• 通讯作者: Ikeda SI.

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Extensive brain pathology in a patient with aceruloplasminemia with a prolonged duration of illness

• DOI: 10.1016/j.humpath.2011.05.016
• 发表时间: 2012-03-01
• 期刊: HUMAN PATHOLOGY
• 影响因子: 3.3
• 作者: Kaneko, Kazuma;Hineno, Akiyo;Ikeda, Shu-ichi
• 通讯作者: Ikeda, Shu-ichi