Research for Antitumor Crude Drug from Malaysian Unutilized Plant Resorces

马来西亚未利用植物资源抗肿瘤药材的研究

• 批准号: 17404005
• 负责人: MORITA Hiroshi
• 金额: $ 6.97万
• 依托单位: Hoshi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17404005/
• 关键词: antitumor; plant; crude drug; Malaysia; 抗マラリア

Malaysia is situated in South East Asia, has one of the oldest and the richest flora in the world. Malaysia has a climate, which is constantly warm, and nearly uniform suitable for the growth of tropical rainforests. Malaysian forest is rather unique in the sense that it serves as a major migratory track for two great floras between the continental Asiatic(extending form Eastern India to Indochina) in the north and the Malaysian flora(extending to all the Malay Archipelago) in the south.Plants were collected from the Malayan flora and their extracts from plants belonging to Meliaceae, Leguminosae, and Apocynaceae were tested for bioactivity. From these studies, a number of cytotoxic and antiplasmodial compounds were isolated and characterized chemically.Five new limonoids, erythrocarpines A-E belonging to mexicanolide-type and A, B, D-seco heptacyclic skeletons were isolated from Chisocheton erythrocarpus, which showed cytotoxicity against P-388 murine leukemia cells. Cassiarins A and B, novel aromatic alkaloids with an unprecedented tricyclic skeleton and potent antiplasmodial activity have been isolated from the leaves of Cassia siamea(Leguminosae), which have been widely used for the treatment of periodic fever and malaria. Huncaniterine A, a new bisindole alkaloid with an N-oxide moiety consisting of corynantheine-type and aspidosperma-type skeletons, which exhibited a moderate vasorelaxant activity on isolated rat aorta ring, has been isolated from the bark of Hunteria zeylanica collected in Kampung Padang, Malaysia.

马来西亚位于东南亚，拥有世界上最古老，最富有的植物之一。马来西亚的气候不断温暖，几乎均匀地适合热带雨林的生长。马来西亚森林是相当独特的，因为它是北部亚洲大陆亚洲（延伸到印度东部向印度东部到印度支那）之间的两个伟大植物的主要迁徙轨道，马来西亚植物群从马来亚植物群及其提取物中收集了植物，并从马来西亚群岛上收集了马来西亚植物，并从马来西亚群岛上收集。生物活性。从这些研究中，分离出许多细胞毒性和抗原毒性化合物，并以化学特征表征。新的柠檬叶，呈墨西哥盐型的红细胞A-E和A，B，D-Seco Heptacyclic骨骼与Chisocheton Erythrocarine cy-cytoxiciiA分离出来。卡西亚林A和B，具有前所未有的三环骨架和有效的抗血流症活性的新型芳香生物碱已从Cassia siamea（豆科）（豆科）的叶子中分离出来，这些骨骼已广泛用于周期性发烧和疟疾的治疗。匈牙利A是一种新的双冬季生物碱，具有N-氧化物部分，由Corynantheine型和Aspidosperma型骨骼组成，表现出对分离的大鼠主动脉环的中等血管长期活性，与H​​unteria Zeylanica collaysia collaysia collaysia collaysia collaysia collaysia collastia collastia collastia collastia collastia collastia collastia collastia collastia collastia collastia collastia collastia collastia sy。

项目成果

Carinatunmins A-C, New Alkaloids from Lycopodium carinatum inhibiting Acetylcholinesterase

Carinatunmins A-C，来自石松的新生物碱抑制乙酰胆碱酯酶

• 发表时间: 2007
• 期刊: Bioorg.Med.Chem 15
• 作者: 荻原国宏;上原忠保;Khalijah Awang;渡辺俊哉・山中修平・上原忠保;Hiroshi Morita;郡山裕作・川俣康憲・上原忠保;Chenn Yan Choo
• 通讯作者: Chenn Yan Choo

Daphmanidins E and F, alkaloids from Daphniphyllum teijsmannii

• DOI: 10.1021/np0503799
• 发表时间: 2006-03-01
• 期刊: JOURNAL OF NATURAL PRODUCTS
• 影响因子: 5.1
• 作者: Morita, H;Ishioka, N;Kobayashi, J
• 通讯作者: Kobayashi, J

Isolation of Active Ingredients from Medicinal Plants

从药用植物中分离活性成分

• 发表时间: 2007
• 作者: Yusuke Hirasawa;Hiroshi Morita;Takaaki Kubota;Yusuke Hirasawa;Hiroshi Morita;Takaaki Kubota;Hiroshi Morita;Hiroshi Morita;Hiroshi Morita
• 通讯作者: Hiroshi Morita

Pordamacrines A and B, alkaloids from Daphniphyllum macropodum

• DOI: 10.1021/np070226g
• 发表时间: 2007-09-01
• 期刊: JOURNAL OF NATURAL PRODUCTS
• 影响因子: 5.1
• 作者: Matsuno, Yosuke;Okamoto, Mariko;Morita, Hiroshi
• 通讯作者: Morita, Hiroshi

Bioactive Peptides from Higher Plants

来自高等植物的生物活性肽

• 发表时间: 2007
• 作者: Yusuke Hirasawa;Hiroshi Morita;Takaaki Kubota;Yusuke Hirasawa;Hiroshi Morita;Takaaki Kubota;Hiroshi Morita;Hiroshi Morita;Hiroshi Morita;Hiroshi Morita;Hiroshi Morita;Hiroshi Morita;Hiroshi Morita
• 通讯作者: Hiroshi Morita