Analysis of Kap proteins, novel kinetochore-binding factors

Kap 蛋白、新型着丝粒结合因子的分析

• 批准号: 20870004
• 负责人: SUGIYAMA Tomoyasu
• 金额: $ 2.11万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20870004/
• 关键词: 染色体分配; キネトコア; CENP-A; キネトコァ

In this study, I have identified two novel proteins of fission yeast, Kap1 and Kap2, both of which associate with kinetochore. kap1 mutation leads to defects in chromosome segregation and DNA damage responses. These results provide a new insight into kinetochore function.

在这项研究中，我确定了两种新型的裂变酵母蛋白，KAP1和KAP2，它们都与动型座相关。 KAP1突变会导致染色体分离和DNA损伤反应的缺陷。这些结果为动力学函数提供了新的见解。