Development of Chiral Azolium Salts as a Phase-Transfer Catalyst

手性唑鎓盐作为相转移催化剂的开发

• 批准号: 20850021
• 负责人: OHMATSU Kohsuke
• 金额: $ 2.1万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20850021/
• 关键词: 有機分子触媒; 不斉合成; オニウム塩; 相間移動触媒

A series of chiral triazolium salts have been designed as a new class of chiral phase-transfer catalyst, and readily prepared from easily available optically pure α-amino acids. The reactivity and selectivity of these chiral triazolium salts as chiral phase-transfer catalysts have been evaluated in the asymmetric cyanation and alkylation under mild liquid-liquid phase-transfer conditions.

一系列手性三唑盐被设计为一类新型手性相转移催化剂，并由容易获得的光学纯α-氨基酸容易地制备。这些手性三唑盐作为手性相转移催化剂的反应性和选择性已得到证实。在温和的液-液相转移条件下评估不对称氰化和烷基化。