Roles of Odz3 in primary cartilage during mandibular condylar development

Odz3 在下颌髁突发育过程中初级软骨中的作用

• 批准号: 20791565
• 负责人: TAKESHITA Nobuo
• 金额: $ 2.75万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791565/
• 关键词: Odz3; 下顎頭; 軟骨; ATDC5; 0dz3; 軟骨細胞

Mandibular condyle has been speculated to develop by differentiation of fibroblast-like cells covering the condyle to chondrocytes ; however, the developmental mechanisms have not been revealed. We used laser-captured microdissection and cDNA microarray analysis to obtain the genes highly expressed in fibroblast-like cells ; one of these genes was Odz3. The temporal and spatial expression of Odz3 mRNA was revealed in mandibular condylar cartilage during early developmental stage in mice and ATDC5 cells, a mouse chondrogenic cell line. These findings suggest that Odz3 might act as a regulatory factor in the early developmental stage of mandibular condylar cartilage.

据推测，下颌髁突是通过覆盖髁突的成纤维细胞样细胞分化为软骨细胞而发育的；然而，发展机制尚未揭示。我们利用激光捕获显微切割和cDNA微阵列分析来获得在成纤维细胞样细胞中高表达的基因；这些基因之一是 Odz3。在小鼠和 ATDC5 细胞（一种小鼠​​软骨形成细胞系）的早期发育阶段，揭示了 Odz3 mRNA 在下颌髁软骨中的时间和空间表达。这些发现表明，Odz3 可能在下颌髁软骨早期发育阶段充当调节因子。

项目成果

Ten-m/Odz3 is expressed in chondrogenic process during mandibular fracture healing

10-m/Odz3 在下颌骨折愈合过程中的软骨形成过程中表达

• 发表时间: 2009
• 作者: Williams JA;Kondo N;Okabe T;Takeshita N;Pilchak DM;Koyama E;Ochiai T;Jensen D;Chu ML;Kane MA;Napoli JL;Enomoto-Iwamoto M;Ghyselinck N;Chambon P;Pacifici M;Iwamoto M;Tomohiro Fukunaga
• 通讯作者: Tomohiro Fukunaga

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

• DOI: 10.1016/j.ydbio.2009.01.031
• 发表时间: 2009-04-15
• 期刊: DEVELOPMENTAL BIOLOGY
• 影响因子: 2.7
• 作者: Williams, Julie A.;Kondo, Naoki;Okabe, Takahiro;Takeshita, Nobuo;Pilchak, Diane M.;Koyama, Eiki;Ochiai, Takanaga;Jensen, Deborah;Chu, Mon-Li;Kane, Maureen A.;Napoli, Joseph L.;Enomoto-Iwamoto, Motomi;Ghyselinck, Norbert;Chambon, Pierre;Pacifici, Maurizio;Iwamoto, Masahiro
• 通讯作者: Iwamoto, Masahiro

下顎頭の軟骨細胞分化におけるOdz3の役割

Odz3 在下颌髁突软骨细胞分化中的作用

• 发表时间: 2008
• 作者: 竹下信郎;村上隆;福永智広;山城隆;宮脇正一;山本照子
• 通讯作者: 山本照子

Novel roles of Ten-m/Odz3 in development of mandibular condylar cartilage

Ten-m/Odz3 在下颌髁软骨发育中的新作用

• 发表时间: 2008
• 作者: Murakami T;Fukunaga T;Takeshita N;Hiratsuka K;Yamashiro T;Abiko Y;Takano-Yamamoto T
• 通讯作者: Takano-Yamamoto T