Functional analysis for LFA-1 and Mac-1 in STZ-induced diabetic animal model

LFA-1和Mac-1在STZ诱导的糖尿病动物模型中的功能分析

• 批准号: 20791277
• 负责人: NODA Kousuke
• 金额: $ 2.75万
• 依托单位: Hokkaido University (2009)Keio University (2008)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791277/
• 关键词: 白血球接着分子; 白血球ローリング; 白血球接着; 糖尿病網膜症; ICAM-1; LFA-1; Mac-1

The purpose of this study is to determine whether the function of LFA-1 and Mac-1, both of which are the counter-receptors for ICAM-1, is upregulated in an animal model of early phase of diabetic retinopathy induced by streptozotocin (STZ). The data provided no evidence showing functional upregulation of LFA-1 and Mac-1. However, PSGL-1, counter-receptor for P-selectin, seemed to be upregulated in STZ-induced diabetic animal model. The current data indicates the functional change of PSGL-1 in chronic inflammation such as diabetes.

这项研究的目的是确定LFA-1和MAC-1的功能（这两者都是ICAM-1的反感受器）是否在由链球菌诱导的糖尿病性视网膜病变早期的动物模型中上调（STZ（STZ） ）。数据没有提供任何证据表明LFA-1和MAC-1的功能上调。然而，P-1，P-Selectin的反受体，在STZ诱导的糖尿病动物模型中似乎被上调。当前的数据表明慢性炎症（例如糖尿病）中PSGL-1的功能变化。

项目成果

眼科血管・リンパ管研究の最前線

眼科血管及淋巴管研究前沿

• 发表时间: 2009
• 作者: Kurihara T;Koizumi H;et al.;野田航介
• 通讯作者: 野田航介