Interaction of nucleoside transport and drug transport in placental trophoblast cells at various stages of pregnancy

妊娠各阶段胎盘滋养层细胞核苷转运与药物转运的相互作用

• 批准号: 20790144
• 负责人: KOSE Noriko
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790144/
• 关键词: 血液胎盤関門; 核酸輸送担体; 薬物輸送担体; adenosine; ddI; AZT; ENT; インテグレーションプロット; 妊娠糖尿; CNT; 胎児発育不全; uridine; TR-TBT; mannitol; イシテグレーションプロット; NBMPR; 薬学; 医療・福祉

Standard methods of drug administration to pregnant woman have not been established. The purpose of this study was to clarify the interactions of nutrient and drug transport mechanisms in the placenta in order to establish safe, effective, and rational treatment methods for pregnant woman. We also aimed to clarify the transport mechanisms of drugs and nutrients in placenta under pathological conditions. As the supply of nucleosides is important for fetal growth, we focused on the interaction of transport mechanisms for drugs and nucleosides in the placenta. The uptake mechanisms of nucleosides in placenta in gestational diabetes was also clarified. These results should be useful for the establishment of standard methods of drug administration for the pregnant woman.

尚未建立孕妇用药的标准方法。本研究的目的是阐明胎盘中营养物质和药物转运机制的相互作用，以期建立安全、有效、合理的孕妇治疗方法。我们还旨在阐明病理条件下药物和营养物质在胎盘中的转运机制。由于核苷的供应对胎儿生长很重要，因此我们重点研究药物和核苷在胎盘中转运机制的相互作用。妊娠糖尿病胎盘中核苷的摄取机制也得到阐明。这些结果应该有助于建立孕妇用药的标准方法。

项目成果

Involvement of equilibrative nucleoside transporters (ENTs) in the uptakes of uridine and didanosine (ddI) at the blood-placenta barrier

平衡核苷转运蛋白 (ENT) 参与血胎盘屏障处尿苷和去羟肌苷 (ddI) 的摄取

• 发表时间: 2008
• 作者: Sato K;Chishu T;Kose N;Nishimura T;Sai Y;Nakashima E
• 通讯作者: Nakashima E

GABA輸送担体(Slc6a13/GAT-2)を介したhypotaurineの胎盤供給機構

通过 GABA 转运蛋白 (Slc6a13/GAT-2) 的亚牛磺酸胎盘供应机制

• 发表时间: 2010
• 作者: 樋口慧;西村友宏;登美斉俊;崔吉道;中島恵美
• 通讯作者: 中島恵美

Potential of various drugs to inhibit nucleoside uptake in rat syncytiotrophoblast cell line, TR-TBT 18d-1

• DOI: 10.1016/j.placenta.2008.01.010
• 发表时间: 2008-05-01
• 期刊: PLACENTA
• 影响因子: 3.8
• 作者: Chishu, T.;Sai, Y.;Nakashima, E.
• 通讯作者: Nakashima, E.

Enhancement of zidovudine uptake by DHEAS in rat placental syncytiotrophoblasts and human CD4(+) T lymphocytes.

DHEAS 增强大鼠胎盘合体滋养细胞和人 CD4(+) T 淋巴细胞对齐多夫定的摄取。

• 发表时间: 2009
• 作者: Nishimura T;Tomi M;Kose N;Sai Y;Nakashima E.
• 通讯作者: Nakashima E.

Involvement of equilibrative nucleoside transporters (ENTs) in the uptakes of uridine and didanosine (ddI) at the blood-placenta barrier.

平衡核苷转运蛋白 (ENT) 参与血胎盘屏障处尿苷和去羟肌苷 (ddI) 的摄取。

• 发表时间: 2008
• 作者: Sato K;Chishu T;Kose N;Nishimura T;Sai Y;Nakashima E.
• 通讯作者: Nakashima E.