Development of a novel therapy using the iron chelator for advanced hepatocellular carcinoma

开发使用铁螯合剂治疗晚期肝细胞癌的新疗法

• 批准号: 20590783
• 负责人: YAMASAKI Takahiro
• 金额: $ 2.91万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590783/
• 关键词: 肝細胞癌; 鉄キレート剤; 肝発癌; Deferoxamine; Deferasirox; 肝発癌ラットモデル; 進行肝細胞癌

We investigated the anti-tumor effect and the fibrosing suppression effect of the iron chelator deferoxamine (DFO) in vitro and in the model rats using diethylnitrosamine and choline-deficient L-amino acid-defined diet. We proved the antiproliferative effect of DFO in hepatoma cell line. In the vivo model, the body weight and liver weight in the DFO therapy group was significantly lower than those in the control group, and the tumor growth was significantly suppressed in the DFO therapy group comparing the control group. The iron chelator has few DNA damage and has the potential of hepatma specific action different from the traditional anticancer drugs. In this study, we founded that the iron chelator has the potential of a novel antiproliferative drug in patients who had advanced hepatocellular carcinoma and were non-responders for anticancer drugs.

我们在体外和使用二乙基亚硝胺和缺乏胆碱的 L-氨基酸限定饮食的模型大鼠中研究了铁螯合剂去铁胺 (DFO) 的抗肿瘤作用和纤维化抑制作用。我们证明了DFO对肝癌细胞系的抗增殖作用。在体内模型中，DFO治疗组的体重和肝脏重量显着低于对照组，并且与对照组相比，DFO治疗组的肿瘤生长显着受到抑制。该铁螯合剂对DNA损伤小，具有不同于传统抗癌药物的肝癌特异性作用潜力。在这项研究中，我们发现铁螯合剂有可能成为一种新型抗增殖药物，用于治疗晚期肝细胞癌且对抗癌药物无反应的患者。

项目成果

Transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma

碘化油和可降解淀粉微球经导管动脉灌注化疗治疗肝细胞癌

• 发表时间: 2010
• 作者: 石田千尋;他;Yamasaki Takahiro
• 通讯作者: Yamasaki Takahiro

Effect of a nutritional therapy using a late evening snack for hepatocellular carcinoma

晚间零食对肝细胞癌的营养治疗效果

• 发表时间: 2010
• 作者: 道堯浩二郎;恩地森一;山崎隆弘
• 通讯作者: 山崎隆弘

肝癌培養細胞株に対するプロテアソームインヒビター Bortezomibの抗腫瘍効果の検討

蛋白酶体抑制剂硼替佐米对培养肝癌细胞株的抗肿瘤作用研究

• 发表时间: 2008
• 作者: Takami Y;Uto H;Takeshita M;Akamatsu E;Moriuchi A;Hasegawa S;Oketani M;Ido A;Kataoka H;Tsubouchi H.;佐伯 一成
• 通讯作者: 佐伯 一成

Current status and future of hepatic arterial infusion chemotherapy for advanced hepatocellular carcioma

肝动脉灌注化疗治疗晚期肝细胞癌的现状与未来

• 发表时间: 2010
• 作者: 細川貴範;黒崎雅之;山崎隆弘
• 通讯作者: 山崎隆弘

肝細胞癌に対する微小デンプン球(Degradable starch microsheres)を用いた新たな肝動脈塞栓療法の開発

利用可降解淀粉微球开发治疗肝细胞癌的新型肝动脉栓塞疗法

• 发表时间: 2008
• 作者: Chiba T;Marusawa H.;山崎隆弘
• 通讯作者: 山崎隆弘