Effect of central nervous system on small intestinal cell growth And apoptosis

中枢神经系统对小肠细胞生长和凋亡的影响

• 批准号: 20590728
• 负责人: KAZUMA Fujimoto
• 金额: $ 2.33万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590728/
• 关键词: 視床下部; 食欲; 代謝調節; 消化吸収; 小腸粘膜増殖; 生理作用; 迷走神経; メタボリック症候群; 生活習慣; 中枢神経; 小腸; 粘膜; 増殖機構; アポトーシス; 摂食中枢; 満腹中枢; アミン類; 糖類; レプチン; グレリン; 小腸培養

The aim of this study is to examine if the hypothalamus, central nervous system, regulates mucosal cell growth and apoptosis in the small intestine. Epithelial homeostasis is balanced by regulation of cell proliferation and cell death.Intestinal mucosal apoptosis decreased by the ventromedial hypothalamus lesions,which induced hyperphagia and obesity. In contrast, sustained anorexia induced by administration of anorectic agents increased intestinal apoptosis. These results indicate that the central nervous system, in addition to local factors, is related to regulation of mucosal homeostasis in the intestinal mucosa.

这项研究的目的是检查下丘脑，中枢神经系统是否调节小肠中的粘膜细胞生长和凋亡。上皮稳态通过调节细胞增殖和细胞死亡而平衡。肠粘膜细胞凋亡因腹侧下丘脑病变降低，这会诱导女性短牙和肥胖症。相比之下，肛门剂施用引起的持续厌食症会增加肠道凋亡。这些结果表明，除局部因素外，中枢神经系统与肠粘膜中粘膜稳态的调节有关。

项目成果

消化器臓器における幹細胞研究の進歩 : In vivo analysis of intestinal stem cells

消化器官干细胞研究进展：肠道干细胞的体内分析

• 发表时间: 2009
• 作者: 大谷顕史;藤本一眞;Kuo K.
• 通讯作者: Kuo K.

Modulation of the transforming growth factor-beta1-induced Smad phosphorylation by the extracellular matrix receptor beta1-integrin.

• 发表时间: 2009
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: H. Hamajima;I. Ozaki;H. Zhang;S. Iwane;Y. Kawaguchi;Yuichiro Eguchi;S. Matsuhashi;T. Mizuta;K. Matsuzaki;K. Fujimoto

Suppression of intestinal mucosal apoptosis by ghrelin in fasted rats.

胃饥饿素对禁食大鼠肠粘膜细胞凋亡的抑制作用。

• 发表时间: 2008
• 期刊: Exp Biol Med 233
• 作者: Park JM;Kakimoto T;Kuroki T;Shiraishi R;Fujise T;Iwakiri R;Fujimoto K.
• 通讯作者: Fujimoto K.

Visceral fat accumulation is the first and second hit pathogenesis for development of nonalcoholic fatty liver disease.

内脏脂肪堆积是非酒精性脂肪肝发展的第一和第二发病机制。

• 发表时间: 2010
• 作者: Eguchi Y;Mizuta T;Kawaguchi Y;Ozaki I;Ono N;Eguchi T;Fujimoto K.
• 通讯作者: Fujimoto K.

Post-allenge hyperglycemia is a significant risk factor for the development of hepatocellular carcinoma in patients with chronic hepatitis C.

过敏后高血糖是慢性丙型肝炎患者发生肝细胞癌的重要危险因素。

• 发表时间: 2011
• 期刊: J Gastroenterol. [Epub ahead of print]
• 作者: Takahashi H;Mizuta T;Eguchi Y;Kawaguchi Y;Kuwashiro T;Oeda S;Isoda H;Oza N;Iwane S;Izumi K;Anzai K;Ozaki I;Fujimoto K.
• 通讯作者: Fujimoto K.