A research for a development of histopathological diagnosis method for schizophrenia on forensic autopsied brains

法医尸检脑组织病理学诊断精神分裂症方法的研究

• 批准号: 20590683
• 负责人: NISHIMURA Akiyoshi
• 金额: $ 3.16万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590683/
• 关键词: 法医病理学; lectin; schizophrenia; apoptosis; neuron; hippocampal formation; multi-fluorescent; single strand DNA; immuno electron microsecope; ChAT; NMDA; AADC; immuno electron microscope

On this research, multi-lectin positive spherical shaped deposits detected in the hippocampal formation of degenerative demented and schizophrenic brains were examined by mean of multi-fluorescent immunohistochemical and lectin histochemical method and immuno electron microscope method. These deposits were detected in cholinergic and glutamatergic neurons and D-neuron at the stage of apoptosis. This result and theories of insufficient migration of neurons in schizophrenic brains are in harmony, which suggests the lectin positive spherical shaped deposits detected in the hippocampal formation is a predominant histopathological marker of the postmortem diagnosis for schizophrenia.

本研究采用多重荧光免疫组化和凝集素组织化学方法以及免疫电镜方法，对退行性痴呆和精神分裂症大脑海马结构中检测到的多重凝集素阳性球形沉积物进行了检测。在凋亡阶段的胆碱能和谷氨酸能神经元以及 D-神经元中检测到这些沉积物。这一结果与精神分裂症患者大脑中神经元迁移不足的理论相一致，这表明在海马结构中检测到的凝集素阳性球形沉积物是精神分裂症死后诊断的主要组织病理学标志。

项目成果

Are lectin positive spherical deposits detected in the molecular layer of the hippocampal formation related with neuronal apoptosis?

海马结构分子层中检测到的凝集素阳性球形沉积物是否与神经元凋亡有关？

• 发表时间: 2010
• 期刊: The Journal of Medical Investigation 57(3,4)
• 作者: Akiyoshi Nishimura

Lectin positive spherical deposits detected in the molecular layer of the hippocampal formation are related with neuronal apoptosis on schizophrenia.

在海马结构分子层中检测到的凝集素阳性球形沉积物与精神分裂症的神经元凋亡有关。

• 发表时间: 2008
• 作者: Akiyoshi Nishimura;Akiyoshi Nishimura;西村明儒;西村明儒;西村明儒
• 通讯作者: 西村明儒

統合失調症の組織診断法開発への取り組みについて

关于开发精神分裂症组织诊断方法的努力

• 发表时间: 2011
• 作者: Akiyoshi Nishimura;Akiyoshi Nishimura;西村明儒
• 通讯作者: 西村明儒