Pathological examination about the effects of angiogenic factors on the exacerbation and the improvement of vascular lesions

血管生成因子对血管病变加重和好转影响的病理学检查

• 批准号: 20590342
• 负责人: NAKANO Toshiaki
• 金额: $ 3.08万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590342/
• 关键词: 血管新生; 動脈硬化; 血管新生因子; VEGF; 病理学

Atherosclerotic diseases are a significant public health problem to prevent. Atherosclerosis is associated with an increased risk of death, especially in coronary heart disease and chronic kidney disease (CKD). We investigated the mechanisms of atherosclerosis proceeded with the focus on angiogenic factors. We revealed that VEGF-A and VEGF-C progressed atherosclerotic lesions of ApoE-KO mice. We also revealed that CKD was associated with an increased risk of coronary heart disease caused by the acceleration of chronic inflammation.

动脉粥样硬化疾病是要预防的重大公共卫生问题。动脉粥样硬化与死亡风险增加有关，尤其是在冠心病和慢性肾脏疾病（CKD）中。我们研究了动脉粥样硬化的机制，重点是血管生成因素。我们揭示了VEGF-A和VEGF-C进行了APOE-KO小鼠的动脉粥样硬化病变。我们还透露，CKD与慢性炎症加速引起的冠状动脉疾病风险增加有关。

项目成果

VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B

• DOI: 10.1152/ajpheart.00015.2009
• 发表时间: 2009-11-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
• 影响因子: 4.8
• 作者: Onimaru, Mitsuho;Yonemitsu, Yoshikazu;Sueishi, Katsuo
• 通讯作者: Sueishi, Katsuo

冠状動脈硬化病変における腎機能と酸化LDL、慢性炎症との関係

肾功能、氧化LDL与冠状动脉粥样硬化病变慢性炎症的关系

• 发表时间: 2010
• 作者: 中野敏昭;二宮利治;鶴屋和彦;清原裕;飯田三雄
• 通讯作者: 飯田三雄