Analysis for carcinogenesis of lung cancer in idiopathic pulmonary fibrosis by inflammation and precancerous change

特发性肺纤维化中炎症及癌前病变对肺癌的致癌作用分析

• 批准号: 20590336
• 负责人: OTA Satoshi
• 金额: $ 3.08万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590336/
• 关键词: 肺がん; 肺癌; 炎症; 前癌状態; 特発性肺線維症

Idiopathic pulmonary fibrosis is the interstitial pneumonia of unknown cause and refractory lesion, with a high risk for lung cancer. To study the difference of squamous cell carcinoma with or without idiopathic pulmonary fibrosis, the transcriptome expression level of each squamous cell carcinoma sample were compared. Famous oncogene MYCN, cytoskeleton protein MYH11, unknown function protein ARMC4 were upregulated. One of downregulated protein was MTSS-1 which supposed to be the role as disassembling the actin fibers.

特发性肺纤维化是一种原因不明的间质性肺炎，是一种难治性病变，具有较高的肺癌风险。为了研究伴或不伴特发性肺纤维化的鳞状细胞癌的差异，比较每个鳞状细胞癌样本的转录组表达水平。著名癌基因MYCN、细胞骨架蛋白MYH11、未知功能蛋白ARMC4表达上调。下调蛋白之一是MTSS-1，其作用可能是分解肌动蛋白纤维。