Functional analyses of transcription factors of ATF-2 gene family members by using knockout mouse

利用敲除小鼠进行ATF-2基因家族成员转录因子的功能分析

• 批准号: 20590294
• 负责人: MAEKAWA Toshio
• 金额: $ 3.08万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590294/
• 关键词: ATF-2; ATF-7; ストレス; 転写制御; エピジェネティクス; 肥満; 行動異常; セロトニン; ATF-2遺伝子ファミリー; ヘテロクロマチン; トリメチル化ヒストンH3K9; ATF-7複合体; DNA修復酵素; CRE-BPa; HTR5B; p38阻害剤; PPARγ2; 肥満予防; 脂肪分化; p38; 阻害剤

By the analyses of knockout mice of the ATF-2 gene family members, I have analyzed the physiological functions of ATF-2 gene family members. I have found that ATF-2 contribute to the developments of central nervous systems and macrophages. ATF-2 and CRE-BPa also contribute to the differentiations to the adipose tissue. On the other hand, ATF-7 represses the transcription of serotonin receptor 5b in the dorsal raphe nucleus in the brain stem. By the depletion of ATF-7, serotonin concentration was reduced and mouse showed abnormal behaviors.

通过对ATF-2基因家族成员敲除小鼠的分析，我分析了ATF-2基因家族成员的生理功能。我发现ATF-2有助于中枢神经系统和巨噬细胞的发展。 ATF-2和CRE-BPA也有助于与脂肪组织的分化。另一方面，ATF-7抑制了脑干背侧raphe核中5-羟色胺受体5b的转录。通过ATF-7的耗竭，血清素浓度降低，小鼠表现出异常行为。

项目成果

Stress-induced epigenetic regulation via ATF-2 family transcription factors

通过 ATF-2 家族转录因子进行应激诱导的表观遗传调控

• 发表时间: 2010
• 作者: S.Ishii;K.Seong;H.Shimizu;D.Li;T.Maekawa
• 通讯作者: T.Maekawa

The role of ATF-2 family transcription factor in adipocyte differentiation : Antiobesity effects of p38 inhibitors.

ATF-2 家族转录因子在脂肪细胞分化中的作用：p38 抑制剂的抗肥胖作用。

• 发表时间: 2010
• 期刊: Mol.Cell.Biol. 30
• 作者: Maekawa T;Jin W;Ishii S
• 通讯作者: Ishii S

Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene

• DOI: 10.1038/emboj.2009.318
• 发表时间: 2010-01-06
• 期刊: EMBO JOURNAL
• 影响因子: 11.4
• 作者: Maekawa, Toshio;Kim, Seungjoon;Ishii, Shunsuke
• 通讯作者: Ishii, Shunsuke

ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells.

• DOI: 10.1016/j.bbrc.2009.05.001
• 发表时间: 2009-07
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: N. Hirose;T. Maekawa;T. Shinagawa;S. Ishii

Socail isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.

社会隔离应激会诱导 ATF-7 磷酸化并损害 5-HT 5B 受体基因的沉默。

• 发表时间: 2010
• 期刊: EMBO J. 29
• 作者: Maekawa T;Kim S-J;Nakai D;Makino C;Takagi T;Orura H;Yamada K;Chatton B;Ishii S
• 通讯作者: Ishii S