Analysis of B-FABP as an immunoregulatory factor by modulating omega-3 polyunsaturated fatty acid metabolism

B-FABP 作为免疫调节因子通过调节 omega-3 多不饱和脂肪酸代谢进行分析

• 批准号: 20590191
• 负责人: TOKUDA Nobuko
• 金额: $ 3.08万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590191/
• 关键词: 脂肪酸; 脂肪酸結合タンパク質(FABP); リンパ節; 線維芽細胞; 肝臓; クッパー細胞; FABP; マクロファージ; リンパ球; サイトカント; サイトカイン; T細胞; 脂肪酸; 脂肪酸結合タンパク質(FABP); リンパ節; 線維芽細胞; 肝臓; クッパー細胞; FABP; マクロファージ; リンパ球; サイトカント; サイトカイン; T細胞

The present study was undertaken to examine the detailed distribution and the function of brain-type fatty acid binding protein (B-FABP/FABP7), a strong binder of omega-3 fatty acids, in mouse peripheral immune organs and immune cells.B-FABP was localized to the fibroblastic reticular cells, which construct the stromal reticula in the T cell areas of the peripheral lymph nodes and spleen. In B-FABP knockout (KO) mice, the percentage of CD4^+ cells in the organs was significantly increased compared with that in wild-type mice.In the liver, B-FABP was exclusively localized in Kupffer cells. Their phagocytic activity and accumulation to injured portion were significantly decreased in KO mice.

进行了本研究以检查脑外围免疫器官和免疫细胞中脑型脂肪酸结合蛋白（B-FABP/FABP7）的详细分布和功能，一种强的omega-3脂肪酸，BB-FABP。脾脏。在B-FABP敲除（KO）小鼠中，与野生型小鼠相比，器官中CD4^+细胞的百分比显着增加。在肝脏中，B-FABP仅位于Kupffer细胞中。在KO小鼠中，它们的吞噬活性和损伤部分的积累显着降低。