Preventive effects of marine carotenoids on life-style-related diseases based on anti-inflammatory effects as molecular targets

以抗炎作用为分子靶标的海洋类胡萝卜素对生活方式相关疾病的预防作用

• 批准号: 20380117
• 负责人: HOSOKAWA Masashi
• 金额: $ 12.4万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380117/
• 关键词: 食品化学; 分子栄養学; カロテノイド; 抗炎症; サイトカイン; 肥満; 大腸癌; マクロファージ; 脂肪組織; 大腸組織; 大腸; 脂肪細胞; 炎症性腸疾患; アスタキサンチン

Astaxanthin exhibited inhibitory effects on dextran sodium sulfate-induced colitis and inflammatory-related colon carcinogenesis in mice. In colon of the mice fed astaxanthin, mRNA expression levels of inflammatory cytokines such as TNF-α and IL-1β were suppressed through inhibition of NF-κB activation. After feeding for 20 weeks, colonic mucosal ulcers, dysplastic crypts and colonic adenocarcinoma were inhibited by 200 ppm astaxanthin-containing diet. In addition, astaxanthin, pectenolone, alloxanthin and diatoxanthin isolated from marine organisms attenuated excessive mRNA expression of inflammatory cytokines and COX-2 and iNOS in macrophages activated by LPS. On the other hand, dietary 0.2% fucoxanthin markedly suppressed mRNA expression of inflammatory cytokines such as TNF-α and IL-6 to induce insulin resistance and inhibited macrophage infiltration in white adipose tissue through suppression of MCP-1 mRNA expression after 4 weeks feeding. Further, fucoxanthinol, which is one of fucoxanthin metabolites, also regulated cross talk of adipocytes and macrophages via palmitic acid and TNF-α. These results suggest that anti-inflammatory effects are molecular mechanism for anti-obesity and anti-diabetic effects of fucoxanthin.

astaxanthin暴露了对硫酸葡萄糖诱导的结肠炎和炎性相关的结肠癌发生的抑制作用。在喂食虾青素的小鼠的结肠中，通过抑制NF-κB激活来抑制炎性细胞因子（例如TNF-α和IL-1β）的mRNA表达水平。喂养20周后，200 ppm含有astaxanthin的饮食抑制了结肠粘膜溃疡，发育不良的隐窝和结肠腺癌。此外，从海洋生物中分离出的astaxanthin，pectenolone，Alloxanthin和diatoxanthin在LPS激活的巨噬细胞中减弱了炎性细胞因子和Cox-2和iNOS的过量mRNA表达。另一方面，饮食中的0.2％葡萄糖黄质明显抑制了炎症细胞因子（如TNF-α和IL-6）的mRNA表达，从而诱导胰岛素抵抗，并通过4周后MCP-1 mRNA表达抑制白色脂肪组织中巨噬细胞抑制。此外，是岩藻黄醇代谢产物之一的岩藻氨甲醇，还通过棕榈酸和TNF-α调节了脂肪细胞和巨噬细胞的交叉谈判。这些结果表明，抗炎作用是岩甘阳蛋白抗肥胖和抗糖尿病作用的分子机制。

项目成果

Anti-inflammatory effects of marine carotenoids on DSS-induced colitis in mice

海洋类胡萝卜素对 DSS 诱导的小鼠结肠炎的抗炎作用

• 发表时间: 2010
• 作者: M.Hosokawa;Y.Yasui;K.Miyashita;T.Tanaka
• 通讯作者: T.Tanaka

カロテノイドの科学と最新応用技術(第7章 予防医学とカロテノイド)

类胡萝卜素科学与最新应用技术（第七章预防医学与类胡萝卜素）

• 发表时间: 2009
• 作者: 安井由美子;田中卓二
• 通讯作者: 田中卓二

Chapter 32. Antiobesity effect of fucoxanthin from edible seaweeds and its multibiological functions., in "Functional Food and Health"

《功能性食品与健康》第32章食用海藻中岩藻黄质的抗肥胖作用及其多生物功能。

• 发表时间: 2008
• 作者: H. Maeda;M. Hosokawa;T. Sashima;K. Miyashita
• 通讯作者: K. Miyashita

Inhibitory effects of fucoxanthin on colitis-related colon carcinogenesis in mice.

岩藻黄质对小鼠结肠炎相关结肠癌的抑制作用。

• 发表时间: 2010
• 作者: Kamiyama;T.;Suzuki;T.;Y.Yasui
• 通讯作者: Y.Yasui

褐藻中に含まれるフコキサンチンに抗肥満作用

褐藻中含有的岩藻黄质具有抗肥胖作用

• 发表时间: 2010
• 作者: M. Shimomura;S. Ohtsuka;J. Hashimoto;細川雅史
• 通讯作者: 細川雅史