Regulation of adipocytes differentiation by marine lipids

海洋脂质对脂肪细胞分化的调节

基本信息

批准号：
17580178
负责人：
HOSOKAWA Masashi
金额：
$ 2.41万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Obesity is now recognized as a world wide problem. It is multiple risk factors for the life style-related diseases such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Visceral fat accumulation plays crucial roles in the development of these diseases. So, it is important to prevent the life style-related diseases through significantly reducing excess accumulation of visceral fat. Fucoxanthin is a major carotenoid found in edible seaweed such as Undaria pinnatifida and Hijikia fusiformis. Fucoxanthin and its metabolite, fucoxanthinol, inhibited intercellular lipid accumulation and suppressed glycerol-3-phosphate dehydrogenase activity during adipocyte differentiation of 3T3-L1 cells. In addition, in 3T3-L1 cells treated with fucoxanthin and fucoxanthinol, peroxisome proliferators-activated receptor (PPAR_γ), which regulates adipogenic gene expression, was down-regulated in a dose-dependent manner. N-3 Highly unsaturated fatty acid, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are major fatty acids in fish oil, also suppressed adipocyte differentiation of 3T3-L1 cells by down regulation PPAR_γ And C/EBP_α. White adipose tissue weight of mice fed fucoxanthin was significantly lower than that of mice fed control diet. Uncoupling protein 1(UCP1), a key molecule for metabolic thermogenesis, was clearly found in WAT of mice fed fucoxanthin. The anti-obesity effect of fucoxanthin was enhanced by the combination with fish oil containing DHA and EPA

肥胖现在被认为是一个全球问题。它是与生活方式有关的疾病（例如糖尿病，高血压，高脂血症和心血管疾病）的多种危险因素。内脏脂肪积累在这些疾病的发展中起着至关重要的作用。因此，重要的是要通过大大减少内脏脂肪的过量积累来防止与生活方式相关的疾病。 fucoxanthin是在可食用的主要类胡萝卜素中，另外发现，在用岩甘阳蛋白和岩甘氨酸和岩存在醇处理的3T3-L1细胞中，过氧化物体增生剂激活受体（PPAR_γ）调节脂肪基因表达，在剂量依赖性的方式中下调。 N-3高度不饱和脂肪酸，二十二碳六烯酸（DHA）和Eicosapentaenoic酸（EPA）是鱼油中主要的脂肪酸，也通过下调调节PPAR_γ和C/EBP_α抑制了3T3-L1细胞的脂肪细胞分化。喂养葡萄存在的小鼠的白脂肪组织重量明显低于喂养饮食的小鼠。解偶偶联蛋白1（UCP1）是一种代谢生热的关键分子，在喂养岩藻糖蛋白的小鼠的WAT中清楚地发现。通过与含有DHA和EPA的鱼油结合的结合，增强了岩藻素蛋白的抗肥胖作用