MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS

迁移细胞和神经元中细胞极化的分子机制

• 批准号: 20227006
• 负责人: KAIBUCHI Kozo
• 金额: $ 124.8万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20227006/
• 关键词: シグナル伝達; 遊走; 細胞骨格; 極性; プロテオーム; 微小管; 脳・神経; 小胞輸送

In response to extracellular and intracellular signals, cell exhibits a polarized morphology with adhering neighboring cells and extracellular matrix. Cell polarization is a fundamental process that makes cells enable to exert specific physiological roles in tissues. The understanding for the molecular mechanisms by which cell polarization isregulated had remained largely unknown. Our researches revealed signaling networks for cellular polarization and its maintenance in migrating cells and neurons.

为了响应细胞外和细胞内信号，细胞表现出极化形态，并粘附相邻细胞和细胞外基质。细胞极化是使细胞能够在组织中发挥特定生理作用的基本过程。对细胞极化调节的分子机制的理解在很大程度上仍然未知。我们的研究揭示了细胞极化的信号网络及其在迁移细胞和神经元中的维持。

项目成果

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia

• DOI: 10.1093/hmg/ddn217
• 发表时间: 2008-10-15
• 期刊: HUMAN MOLECULAR GENETICS
• 影响因子: 3.5
• 作者: Ikeda, Masashi;Hikita, Takao;Iwata, Nakao
• 通讯作者: Iwata, Nakao

Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes.

• DOI: 10.1152/ajpcell.00038.2011
• 发表时间: 2011-07
• 期刊: American journal of physiology. Cell physiology
• 作者: C. Routray;Chunsheng Liu;Usman Yaqoob;D. Billadeau;K. Bloch;K. Kaibuchi;V. Shah;N. Kang

Identification of Focal Adhesion Kinase (FAK) and Phosphatidylinositol 3-kinase (PI3-kinase) as Par3 Partners by Proteomic Analysis

• DOI: 10.1002/cm.20444
• 发表时间: 2010-05-01
• 期刊: CYTOSKELETON
• 影响因子: 2.9
• 作者: Itoh, Norimichi;Nakayama, Masanori;Kaibuchi, Kozo
• 通讯作者: Kaibuchi, Kozo

Neurotrophins specify axonal fate of hippocampal neurons acting through inositol 1, 4, 5-triphosphate and Ca^<2+>

神经营养素通过肌醇 1,4,5-三磷酸和 Ca^2 作用指定海马神经元的轴突命运

• 发表时间: 2011
• 作者: Shimomura A;Ohama T;Hori M;Ozaki H;黒柳美和ら;Kaibuchi K.
• 通讯作者: Kaibuchi K.

神経研究とプロテオミクス:質量分析計に何ができるのか

神经学研究和蛋白质组学：质谱仪能做什么？

• 发表时间: 2011
• 作者: Wada;M.;Kaibuchi K.
• 通讯作者: Kaibuchi K.