Effect of therapeutic exercise on muscle regeneration -Formation of myotubes and environment-

治疗运动对肌肉再生的影响-肌管的形成和环境-

• 批准号: 10838012
• 负责人: HAIDA Nobuhide
• 金额: $ 1.66万
• 依托单位: KANAZAWA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10838012/
• 关键词: therapeutic exercise; muscle regeneration; myotube; fibroblast growth factor; collagen; fibronectin; lamininn; フィプロネクチン; 筋衛星細胞; 組織修復; 線維芽増殖因子; IV型コラーゲン

The therapeutic exercise from early phase after tissue degeneration does not give a disorder to the migration or infiltration capacity of a phagocyte. Inducing the activation and proliferation of a muscle satellite cell that are a precursor cell related to muscle trimming that the regeneration of the muscular tissue is accelerated was proved. What kind of role minute environment is playing to the regeneration of a myocyte in therapeutic exercise subsequently was examined. A sponge made of polyvinyl alcohol was buried to the rat gastrocnemius muscle and was crowded and carried out therapeutic exercise. A sponge examined the appearance of the myotube cell that approached into a sponge and do coating with a fibroblast growth factor, type IV collagen laminin and fibronectin. When type IV collagen and fibronectin exist it is thought that the migration and proliferatin of the myotube cell be important as the substance that gives a clue to the differentiation of a myoblast and become brisk. As for laminin the strong proliferate action of fibroblast was recognized without the proliferation of a myoblast being stimulated. From over, therapeutic exercise induced the regeneration of a myocyte. When collagen and fibronectin exist in the case, a frequency of the onset of the myotube cell elevates more and more and muscle regeneration considered accelerating more.

从组织变性后的早期阶段开始的治疗练习不会对吞噬细胞的迁移或浸润能力造成障碍。已证明，通过诱导作为与肌肉修剪相关的前体细胞的肌肉卫星细胞的活化和增殖，可以加速肌肉组织的再生。随后研究了治疗运动中微小环境对肌细胞的再生发挥什么样的作用。将聚乙烯醇制成的海绵埋入大鼠腓肠肌并进行挤塞，进行治疗运动。用海绵检查肌管细胞的外观，该肌管细胞接近海绵并涂有成纤维细胞生长因子、IV型胶原层粘连蛋白和纤连蛋白。当IV型胶原和纤连蛋白存在时，认为肌管细胞的迁移和增殖作为为成肌细胞的分化提供线索并变得活跃的物质是重要的。对于层粘连蛋白，在不刺激成肌细胞增殖的情况下，认识到成纤维细胞的强烈增殖作用。从那时起，治疗性运动诱导了肌细胞的再生。当胶原蛋白和纤连蛋白存在于情况下时，肌管细胞的出现频率越来越升高，并且肌肉再生被认为更加加速。

项目成果

灰田信英、山崎俊明: "Endurance exercise promotes to repair of injured skeletal muscle in rats" Physical Therapy. 26・3. (1999)

Nobuhide Haida、Toshiaki Yamazaki：“耐力运动促进大鼠受伤骨骼肌的修复”物理治疗26・3。

Nobuhide Haida: "Preventive effect of passive range of motion exercise on denervation-induced muscle atrophy"Memoirs of Faculty of Medicine, Kanazawa University. 23. 55-58 (1999)

Nobuhide Haida：“被动活动范围运动对去神经引起的肌肉萎缩的预防作用”金泽大学医学部回忆录。

灰田信英 他: "Effects of Weight Bearing in cervals on disinse atrophy of rat soleus muscle" Jounal of Japanese Physical Therapy. 1・1. 19-24 (1998)

Nobuhide Haida 等：“鹿类负重对大鼠比目鱼肌疾病性萎缩的影响”日本物理治疗杂志 1・1（1998 年）。

Toshiaki Yamazaki: "Effect of Weight Bearing intervals on disuse atrophy"Journal of the Japanese Physical Therapy. 1. 19-24 (1998)

Toshiaki Yamazaki：“负重间隔对废用性萎缩的影响”日本物理治疗杂志。

Nobuhide Haida: "The effects of ultrasound irradiation and static stretching on immobilized muscle"Journal of Physical Therapy. 25. 368-375 (1998)

Nobuhide Haida：“超声波照射和静态拉伸对固定肌肉的影响”物理治疗杂志。