Gene expression profiles in endometrial carcinoma

子宫内膜癌的基因表达谱

• 批准号: 19591939
• 负责人: NISHIKAWA Hiroshi
• 金额: $ 2.91万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591939/
• 关键词: 婦人科腫瘍学; 子宮体癌; 分子診断; プロファイル; 遺伝子

The gene expression profiles of human endometrial carcinoma were analysed by serial of gene expression (SAGE) which allows quantitative and simultaneous analysis of a large number of transcripts. More than 22000 transcripts deriverd from a normal endometrial tissue and endometrial carcinoma tissue were analysed. While extensive similarity was noted between the expression profiles of the normal endometrial tissue and endometrial carcinoma tissue, many transcripts, such as B-factor properdin, uridine phosphorylase, and cyclin G1 interacting protein, were expressed at extremely different levels in differentiated and undifferentiated carcinoma. These data provide new information that might be used to identify genes useful for the diagnosis and treatment of endometrial carcinoma.

通过基因表达序列 (SAGE) 分析人类子宫内膜癌的基因表达谱，SAGE 可以对大量转录本进行定量和同步分析。对来自正常子宫内膜组织和子宫内膜癌组织的超过 22000 个转录本进行了分析。虽然正常子宫内膜组织和子宫内膜癌组织的表达谱存在广泛相似性，但许多转录物，如 B 因子备解素、尿苷磷酸化酶和细胞周期蛋白 G1 相互作用蛋白，在分化和未分化癌中以极其不同的水平表达。这些数据提供了新的信息，可用于识别对子宫内膜癌的诊断和治疗有用的基因。