CLINICOPATHOLOGIC STUDIES FOR HISTOLOGICAL CLASSIFICATION AND PROGNOSIS OF RHABDOMYOSARCOMA

横纹肌肉瘤组织学分类和预后的临床病理学研究

基本信息

批准号：
10670187
负责人：
HASEGAWA Tadashi
金额：
$ 1.15万
依托单位：
NATIONAL CANCER CENTER
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

1) We reviewed 6 cases of rhabdomyosarcoma as a rare second primary malignancy in children with bilateral retinoblastoma after irradiation treatment. We have concluded that knowledge of the occurrence of rhabdomyosarcoma and appropriate immunohistochemical study are helpful for avoiding a misdiagnosis of recurrent retinoblastoma or Ewing's sarcoma when encountering these patients who developed second small round cell neoplasms.2) We studied immunoreactivity for E-cadherin, the major cadherin of epithelial cells, in 77 cases of a variety of bone and soft tissue sarcomas. We found that E-cadherin was expressed in certain kinds of soft tissue sarcomas, especially those with epithelioid features, suggesting that E-cadherin plays a role in the constitution of their architecture.3) We conducted clinicopathologic study for 24 cases of extrathoracic solitary fibrous tumor that should be differentiated from spindle cell rhabdomyosarcoma, and found their histological variability and potentially aggressive behavior.4) We investigated the prognostic relevance of a histological grading system based on the assessment of proliferative activity in 95 cases of adult soft-tissue sarcomas including 3 rhabdomyosarcomas of the extremities, trunk, head, and neck. An objective histological grading system using ki-67 (MIB-1) was concluded to be more accurate in accessing ability to metastasize, which was strongly correlate with overall survival.

1) 我们回顾了 6 例双侧视网膜母细胞瘤儿童放射治疗后罕见的第二原发恶性肿瘤横纹肌肉瘤病例。我们得出的结论是，在遇到第二个小圆细胞肿瘤的患者时，了解横纹肌肉瘤的发生和适当的免疫组织化学研究有助于避免误诊复发性视网膜母细胞瘤或尤文氏肉瘤。2）我们研究了E-钙粘蛋白的免疫反应性，E-钙粘蛋白是主要的免疫反应性。 77例各种骨和软组织肉瘤中的上皮细胞钙粘蛋白。我们发现E-cadherin在某些软组织肉瘤中表达，特别是那些具有上皮样特征的软组织肉瘤，表明E-cadherin在其结构的构成中发挥作用。3）我们对24例胸外孤立性纤维瘤进行了临床病理学研究。肿瘤应与梭形细胞横纹肌肉瘤相鉴别，并发现其组织学变异性和潜在的侵袭行为。4）我们研究了组织学的预后相关性分级系统基于对 95 例成人软组织肉瘤（包括 3 例四肢、躯干、头部和颈部横纹肌肉瘤）增殖活性的评估。结论是，使用 ki-67 (MIB-1) 的客观组织学分级系统在评估转移能力方面更为准确，这与总体生存率密切相关。