Changes in genes expression following traumatic brain injury

创伤性脑损伤后基因表达的变化

• 批准号: 19689015
• 负责人: SHOJO Hideki
• 金额: $ 16.47万
• 依托单位: University of Yamanashi (2008-2009)Saga University (2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19689015/
• 关键词: 頭部外傷; 受傷応答メカニズム; アポトーシス; マイクロアレイ解析

The ratios of most apoptosis-related gene transcripts changed primarily at 6 and 12 h following traumatic brain injury (TBI). The altered expression ratio decreased significantly at 48 h after trauma. The dynamic changes in expression of apoptosis-related genes were closely paralleled by similar alterations in inflammation-related genes after trauma. The altered genes involved in TBI-induced apoptosis included interleukin 1 and tumor necrotic factor which immediately increased and reached the maximum levels at 3 h following the injury. These results suggested that TBI induced apoptosis relate to inflammation response after trauma.

创伤性脑损伤（TBI）后，大多数与凋亡相关的基因转录物的比率主要在6和12小时变化。创伤后48小时，表达比的改变显着降低。与创伤后炎症相关基因的类似变化，与凋亡相关基因表达的动态变化紧密相似。涉及TBI诱导的凋亡的基因改变的基因包括白介素1和肿瘤坏死因子，这些因子立即增加并在损伤后3小时达到最大水平。这些结果表明，TBI诱导的凋亡与创伤后的炎症反应有关。

项目成果

脳挫傷により誘導されるアポトーシスの経時的解析

脑挫裂伤诱导细胞凋亡的时程分析

• 发表时间: 2007
• 作者: 猩々英紀;木林和彦
• 通讯作者: 木林和彦

Unexpected death due to intestinal obstruction by duplication cyst in an infant.

婴儿因重复囊肿肠梗阻而意外死亡。

• 发表时间: 2007
• 期刊: Forensic Science International 173
• 作者: Kibayashi K;Sumida T;Shojo H;Tokunaga O.
• 通讯作者: Tokunaga O.

DJ-1, a key neuroprotective protein against Parkinson's disease, ameliorates neuronal cell death in ischemic stroke possibly via mitochondrial pathway.

DJ-1 是一种针对帕金森病的关键神经保护蛋白，可能通过线粒体途径改善缺血性中风中的神经元细胞死亡。

• 发表时间: 2010
• 作者: Kaneko Y;Shojo H;Yu S;Bae E;Borlongan CV.
• 通讯作者: Borlongan CV.

頭部外傷により引き起こされるアポトーシスとマクロファージや神経細胞との関係

头部外伤诱导的细胞凋亡与巨噬细胞、神经元的关系

• 发表时间: 2008
• 作者: 猩々英紀;木林和彦
• 通讯作者: 木林和彦

Brain germinoma in young adult male with suspicion of fatal neglect.

疑似致命忽视的年轻成年男性脑生殖细胞瘤。

• 发表时间: 2008
• 期刊: The American Journal of Forensic Medicine and Pathology (in press)
• 作者: Possemato R;Timmons JC;Bauerlein EL;Wada N;Baldwin A;Masutomi K;HahnWC;Kazuhiko Kibayashi
• 通讯作者: Kazuhiko Kibayashi