An investigation on the neural network for impaired articulation using non-invasive functional brain imaging

使用非侵入性功能性脑成像对关节受损的神经网络进行研究

基本信息

批准号：
18390553
负责人：
ONO Takashi
金额：
$ 10.46万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390553/
关键词：
impaired speech covert speech overt speech cleft lip and palate velar plosive fMRI central nervous system 脳賦活代償性構音構音点破裂音脳賦活パタン小脳

项目摘要

Neural networks for speech may be subdivided into two stages, such as the imaginary and executive stages, and products from these stages are called covert and overt speech, respectively. On the other hand, subjects with cleft lip and palate (CLP) axe known to show impaired speech, or compensatory misarticulation. Previous studies showed that these were significant differences between subjects with and without CLP in 1) the activated pattern in the brain during articulation (Shinagawa, et al., 2006), and 2) the movement pattern of the articulators (Sato-Wakabayashi, et al., 2008). However, the responsible stage for the difference in articulation between those with and without CLP was unknown. Adult subjects with [unilateral (UCLP) and bilateral (BCLP)l and without CLP were recruited. We used a 1.5 T MR apparatus. Functional MRI data were taken while the subject repeated the velar plosive, /ka/, at 1.5 Hz for either covert (C) or overt (O) speech in the block design SPM2 was used for analysis. It was shown that the premotor area was activated during C speech in subjects with and without CLP. During O speech, the premotor area, the primary motor cortex and the cerebellum were activated in subjects with UCLP and those without CLP,. On the other hand, these areas were not activated but the posterior cingulate gyrus was activated in the subject with BCLP. These findings suggest that there seems to be little difference in the imaginary stage, but there are differences in the executive stage for articulation between subjects with and without CLP. It appears that several factors including types of the cleft, the difference in the motor outputs and sensory inputs, the types and severity of misarticulation and the timing and effect of speech therapy maybe involved in the difference.

语音的神经网络可以分为两个阶段，例如虚构的阶段和执行阶段，这些阶段的产品分别称为秘密和公开语音。另一方面，已知的嘴唇和pa裂（CLP）斧头的受试者已知言语受损或补偿性错误。先前的研究表明，这些受试者之间有和没有CLP的受试者在1）表达过程中大脑中的激活模式之间存在显着差异（Shinagawa等，2006）和2）关节轴的运动模式（Sato-Wakabayashi，et et and。 Al。，2008）。但是，对于没有CLP和没有CLP的人之间发音差异的负责任阶段是未知的。招募了[单侧（UCLP）和双侧（BCLP）L和没有CLP的成年受试者。我们使用了1.5吨MR设备。当受试者以秘密（C）为1.5 Hz的主题重复使用Velar Plosive（C）或块设计SPM2中的公开（O）语音进行分析时，获取功能性MRI数据。结果表明，在有和没有CLP的受试者中，在C语音中激活了前运动区域。在O语音期间，在患有UCLP的受试者和没有CLP的受试者中，将前运动皮层和小脑的主要运动皮层和小脑被激活。另一方面，这些区域没有被激活，但在受试者中用BCLP激活了后扣带回回。这些发现表明，虚构阶段似乎没有什么差异，但是在有和没有CLP的受试者之间表达的执行阶段存在差异。看来，包括裂缝的类型，电动机输出和感觉输入的差异，差异的类型和严重性以及言语治疗的时间和效果，可能与差异有关。