Neural control of hyperactivity and spasm in the masticatory muscles.

咀嚼肌过度活跃和痉挛的神经控制。

基本信息

批准号：
07407053
负责人：
MORIMOTO Toshifumi
金额：
$ 13.82万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

It is suggested that hyperactivity or spasm in the masticatory muscles cause the temporomandibular joint disorders. However the neural mechanism of the hyperactivity has not bee found clealy. To investigate this mechanism we have done following six experiments. (1) effect of the hardness of food on the control of masticatory force. (2) role of the muscle spindle afferents on the control of masticatory force. (3) modulation of jaw muscle spindle discharge during mastication in the awake animals (4) classification of the jaw muscle spindle afferents (5) influence of the biogenic amine on the membrane charactaristics of the trigeminal motoneurons (6) relationship between the taste rejection behavior and salivation.Results were as follows :(1) During cortically induced rhythmic jaw movements (CRJMs) in anesthetized rabbits, chewing of the harder test strips induced the larger EMG activities of the jaw closing muscle. (2) We observed the correlation between the magnitude of the masticatory force and the firing frequency of the spindle afferent of masticatory muscle. (3) The difference in the firing pattern among masticatory stages may be ascribed to a stage-dependent modulation of both fusimotor activity and jaw movement pattern. (4) We found the possibility that the jaw muscle spindle afferents may be calssified into two groups on the basis of the firing pattern in the response to the ramp-and-hold stretch. (5) Intracellular calcium concentration may modulate the effect of the biogenic amine on the afterdepolarization in the trigeminal motoneurons. (6) The parabrachial nucleus may play an important role on salivation induced by the rejectable taste.

有人认为，颞下颌关节紊乱是由咀嚼肌过度活跃或痉挛引起的。然而，多动症的神经机制尚未明确。为了研究这种机制，我们做了以下六个实验。 (1)食物的硬度对咀嚼力控制的影响。 (2)肌梭传入神经对咀嚼力控制的作用。 (3) 清醒动物咀嚼过程中颌肌梭放电的调节 (4) 颌肌梭传入神经的分类 (5) 生物胺对三叉神经运动神经元膜特征的影响 (6) 味觉排斥行为之间的关系结果如下：（1）在麻醉兔子的皮质诱导的有节奏的下颌运动（CRJM）中，咀嚼较硬的试纸会引起更大的试纸下颌闭合肌的肌电图活动。 (2)观察咀嚼力大小与咀嚼肌纺锤体传入神经放电频率之间的相关性。 (3)咀嚼阶段之间放电模式的差异可能归因于咀嚼运动活动和下颌运动模式的阶段依赖性调节。 (4)我们发现下颌肌梭传入神经可能根据斜坡和保持拉伸反应的放电模式分为两组。 (5)细胞内钙浓度可能调节生物胺对三叉神经运动神经元后去极化的影响。 (6)臂旁核可能在拒味引起的流涎中起重要作用。