Evaluation of left ventricular torsion by two dimensional tissue tracking system

二维组织跟踪系统评价左心室扭转

• 批准号: 18500378
• 负责人: MURATA Kazuya
• 金额: $ 2.52万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500378/
• 关键词: Ultrasonics; Heart Failure; Echocardiograoh; Physiology; Cardiology

Background: The Two-Dimensional Tissue Tracking (2DTT) technique can trace regional myocardial tissue using pattern matching method. The 2DTT has a capability to clinically evaluate the left ventricular (LV) torsion in endocardium (Endo) and epicardium (Epi) separately. Our objective was to characterize the response of LV torsion to low-dose dobutamine (Dob)infusion using 2DTT in idiopathic dilated cardiomyopathy (DCM). Methods: Ten patients with DCM were studied. We acquired LV basal and apical short-axis views both at rest and during Dob infusion (5, 10μg/kg/min) using Hitachi EUB-7500 ultrasound machine equipped with 2DTT software. Eight points were manually placed both at Endo and Epi equally in each basal and apical view. The movements of these points were automatically tracked by the system throughout a cardiac cycle. The center of rotation in each frame was determined by customized software, and rotation angle of each point was calculated and averaged. The LV torsion was defined as net-difference between basal and apical rotation angle. LV end-diastolic volume and LV end-systolic volume (ESV)were assessed by the biplane Simpson's equation. Results: Seven of 10 patients showed more than 10% reduction in ESV after 10μg/kg/min Dob infusion(responder). In responders, both apical Endo and Epi rotation increased at 10μg/kg/min Dob infusion (Endo: 1.2±1.1 to 3.6±1.8°, Epi: 0.8±0.7 to 2.3±1.2, p<0.01, respectively), however, basal rotation angles unchanged throughout of study. Consequently, the LV torsion in Endo and Epi increased after Dob infusion (Endo: 3.1±1.7 to 5.7±1.6°, Epi: 2.4±1.0 to 4.6±1.7, p<0.05, respectively).On the other hand, in patients with poor LV response to Dob infusion, basal and apical rotation angles unchanged during Dob infusion. Conclusions: The augmentation of LV rotation was observed especially in apex by inotropic stimulation, which may reflect myocardial contractile reserve in DCM.

背景：二维组织追踪（2DTT）技术可以使用模式匹配方法追踪局部心肌组织，2DTT 能够在临床上分别评估心内膜（Endo）和心外膜（Epi）的左心室（LV）扭转。目的是使用 2DTT 描述特发性扩张型心肌病中左室扭转对低剂量多巴酚丁胺 (Dob) 输注的反应方法：我们使用配备 2DTT 软件的 Hitachi EUB-7500 超声机对 10 名 DCM 患者进行了研究，获得了静息时和 Dob 输注（5、10μg/kg/min）期间的 LV 基底和心尖短轴视图。在每个基底视图和心尖视图中手动放置八个点，系统在整个心动周期中自动跟踪这些点的运动，并确定每个帧中的旋转中心。通过定制软件计算每个点的旋转角度并求平均值，将左室扭转定义为双翼飞机评估的左室舒张末期容积和左室收缩末期容积（ESV）之间的净差。辛普森方程：10 名患者中的 7 名在 10μg/kg/min Dob 输注后显示 ESV 降低超过 10%（应答者），均为心尖部患者。 Endo 和 Epi 旋转在 10μg/kg/min Dob 输注时增加（Endo：分别为 1.2±1.1 至 3.6±1.8°，Epi：分别为 0.8±0.7 至 2.3±1.2，p<0.01），然而，基础旋转角度在整个过程中保持不变研究显示，注射 Dob 后，Endo 和 Epi 的左室扭转增加（Endo：3.1±1.7 至5.7±1.6°，Epi：分别为2.4±1.0至4.6±1.7，p<0.05）。另一方面，在左心室对Dob输注反应较差的患者中，Dob输注期间基底和心尖旋转角度不变。观察到左室旋转增强，特别是在心尖部，通过正性肌力刺激，这可能反映了 DCM 中的心肌收缩储备。

项目成果

Maturational Modulation of Right Ventricular Longitudinal and Radial Strain : Comparison with Left Ventricle using Two Dimensional Tissue Tracking System

右心室纵向和径向应变的成熟调节：使用二维组织跟踪系统与左心室进行比较

• 发表时间: 2007
• 作者: Yasuaki;Wada
• 通讯作者: Wada

心臓再同期療法の左室捻れ運動に及ぼす影響-Two dimensional tissue tracking法による検討-

心脏再同步治疗对左心室扭转运动的影响 - 使用二维组织跟踪方法的研究 -

• 发表时间: 2007
• 作者: Takeo;Tanaka;田中 健雄;村田 和也;Eizo Akagawa;Takeo Tanaka;Eizo Akagawa;Yasuaki Wada;Takeo Tanaka;Takeo Tanaka;Takeo Tanaka;田中 健雄
• 通讯作者: 田中 健雄

Transmural gradient of Left Ventricular Systolic Torsion in Patients with Left Ventricular Hypertrophy

左心室肥厚患者左心室收缩期扭转的透壁梯度

• 发表时间: 2007
• 作者: Hong;J.;Matsumoto;N.;Ouchida;R.;Komune;S.;Hashizume;M;Takeo Tanaka;Takeo Tanaka
• 通讯作者: Takeo Tanaka

肥大型心筋症における左室局所捻じれ運動の検討

肥厚型心肌病左心室局部扭转运动的检查

• 发表时间: 2006
• 作者: 吉田昌弘;片寄正樹;谷口圭吾;田中 健雄;田中 健雄
• 通讯作者: 田中 健雄

左室拡張早期流入時における僧帽弁輪動態の評価:左室長軸方向および短軸方向からの検討

左心室舒张早期血流期间二尖瓣环动力学的评估：从左心室长轴和短轴方向检查

• 发表时间: 2006
• 作者: Takeo;Tanaka;赤川 英三;和田 靖明
• 通讯作者: 和田 靖明