Identification of suicide candidate genes in amygdala and its application to neuroimaging studies

杏仁核自杀候选基因的鉴定及其在神经影像学研究中的应用

基本信息

批准号：
17390319
负责人：
SHIRAKAWA Osamu
金额：
$ 10.25万
依托单位：
Kinki University (2007)Kobe University (2005-2006)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390319/
关键词：
suicide biology gene polymorphism gene expression amygdala neuroendocrinology neuroimaging cognition

项目摘要

1. We studied the clinical and psychological characteristics associated with suicidality based on the history of lethal suicide attempt in 76 patients mainly with mood disorders. Hopelessness rather than depression, aggression in less than 40 years old patients and neuroticism were associated with suicidality. The perspectives on death were not associated with suicidality.2. We performed the profiling of mRNA expressions in amygdala of suicide brains. The 21 increased and the 9 decreased expressions of genes were identified. Among the genes with increased expressions, the polymorphisms of 14-3-3 ε gene were associated with suicide. Any polymorphisms in genes with the decreased expressions were not associated with suicide.3. Among the functional gene polymorphisms which affect a hypothalamic-pituitary-adrenal system (HPA system), we found the significant associations of OPRM1 Asn40Asp, ACE I/D and ADEA2A C-1291G polymorphism with suicide.4. For functional MRI, we made a neuropsychological task which activates emotion. A stronger activation in amygdala and posterior cingulate gyrus was shown in case of recognition in emotionally negative words, compared with emotionally neutral words. We made the tasks comprising the recall of past negative or positive episodes and the imagination of future negative or positive episodes. The activations were found in the medial frontal cortex, dorsolateral prefrontal cortex posterior cingulate gyrus.

1. 我们根据 76 名患者的致命自杀企图史，研究了与自杀相关的临床和心理特征，主要表现为情绪障碍、40 岁以下患者的攻击性和神经质与自杀相关。 2.我们对自杀大脑杏仁核中的 mRNA 表达进行了分析，其中 21 个基因表达增加，9 个基因表达减少。 14-3-3ε基因多态性与自杀相关，14-3-3ε基因多态性与自杀无关。3．（HPA 系统），我们发现 OPRM1 Asn40Asp、ACE I/D 和 ADEA2A C-1291G 多态性与4. 对于功能性 MRI，我们进行了一项激活情绪的神经心理学任务，与识别情绪中性单词相比，杏仁核和后扣带回的激活更强。过去的消极或积极事件以及对未来消极或积极事件的想象在内侧额叶皮层、背外侧前额叶皮层后扣带回中发现了激活。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia

DOI：
10.1016/j.schres.2007.11.042
发表时间：
2008-03
期刊：
Schizophrenia Research
影响因子：
4.5
作者：
M. Yanagi;T. Hashimoto;N. Kitamura;M. Fukutake;O. Komure;N. Nishiguchi;T. Kawamata;K. Maeda;O. Shirakawa
通讯作者：
M. Yanagi;T. Hashimoto;N. Kitamura;M. Fukutake;O. Komure;N. Nishiguchi;T. Kawamata;K. Maeda;O. Shirakawa

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