Oxytocin regulates stress response and anxiety through functional modulation of amygdala

催产素通过杏仁核的功能调节来调节压力反应和焦虑

基本信息

批准号：
17300127
负责人：
MATSUI Hideki
金额：
$ 9.66万
依托单位：
OKAYAMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300127/
关键词：
Oxytocin RGS2 restrain stress anxiety RGS2 シナプス可塑性記憶・学習マイクロアレイ PKC

项目摘要

Oxytocin is a peptide hormone that causes uterine contraction and facilitates the delivery of the newborn, and stimulates the milk ejection during motherhood. Abundant oxytocin receptors also appear in central nervous system (CNS), especially in limbic system. Oxytocin is involved in the regulation of social behaviors, including maternal care, affiliation and social behaviors in CNS.Moreover, recent studies have shown that oxytocin has anti-anxietic effect during motherhood. However, the exact molecular mechanism is unclear.In the course of experiments under the Monbusho grant, we identified a crucial molecule involved in the regulation of anxiety by oxytocin. Oxytocin induced the expression of Regulator of G-protein Signaling2 (RGS2), which is known as a modulator of anxiety, in the amygdala slices of female mice. RGS2 expression in the amygdala of lactating mice was significantly higher than that of virgin mice. Moreover, the expression of RGS2 in virgin mice undergone restraint stress was facilitated compared with that of control mice. These data agree with our hypothesis that the brain hormone oxytocin controls anxiety and stress response by increase of RGS2 expression in amygdala neurons. We will further examine the molecular mechanism of anxiety control by oxytocin in amygdala.

催产素是一种肽激素，可引起子宫收缩并促进新生儿的递送，并在孕产期间刺激牛奶的喷射。大量的催产素受体也出现在中枢神经系统（CNS）中，尤其是在边缘系统中。催产素参与了社会行为的调节，包括孕产妇护理，隶属关系和社会行为。此外，最近的研究表明，催产素在孕产期间具有抗Xietigin效应。然而，确切的分子机制尚不清楚。在Monbusho Grant下的实验过程中，我们确定了与催产素调节焦虑有关的关键分子。催产素在雌性小鼠的杏仁核切片中诱导了G蛋白信号2（RGS2）的调节剂的表达，该调节剂被称为焦虑调节剂。泌乳小鼠杏仁核中的RGS2表达明显高于维尔京小鼠。此外，与对照小鼠相比，在维尔京小鼠中，RGS2的表达促进了约束应力。这些数据与我们的假设一致，即脑激素催产素通过增加杏仁核神经元中RGS2表达来控制焦虑和压力反应。我们将进一步研究杏仁核中催产素控制焦虑的分子机制。