Towards an improved understanding of myometrial quiescence and contraction: Differential regulation via G-protein coupled receptors (GPCRs) and control by regulator of G-protein signaling 2 (RGS2)

加深对子宫肌层静止和收缩的理解：通过 G 蛋白偶联受体 (GPCR) 进行差异调节以及通过 G 蛋白信号传导 2 (RGS2) 调节器进行控制

• 批准号: 419985
• 负责人: Slater Donna M
• 金额: $ 39.85万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=419985&lang=en
• 关键词: G-Protein Coupled Receptors; Molecular Knockdown/Knockout; Molecular Physiology; Myometrium; Parturition; Preterm Labour; Primary Myometrial Cell Culture; Prostaglandin Pathway; Regulator Of G Protein Signaling; Uterine Contractility

Preterm labour and delivery before 37 weeks of pregnancy is a serious health problem. Babies, born too soon, may face difficulties breathing, suffer with brain injury or long-term disability. Unfortunately, current clinical treatments to stop preterm labo

早产和怀孕 37 周之前的分娩是一个严重的健康问题。出生过早的婴儿可能会面临呼吸困难、脑损伤或长期残疾。不幸的是，目前阻止早产的临床治疗