Efficacy of therapy for osteoporosis on oral health

骨质疏松症治疗对口腔健康的疗效

• 批准号: 16390616
• 负责人: INAGAKI Koji
• 金额: $ 8.45万
• 依托单位: Aichi-Gakuin Unviersity
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390616/
• 关键词: osteoporosis; bone mineral density; periodontal disease; community periodontal index; fractal dimension; bisphosphonate

The purpose of the present study was to determine the relationship between periodontal status and panoramic radiographic measures (cortical shape and fractal dimension of the mandible) in postmenopausal women with osteoporosis, and compare the periodontal status of them who use bisphosphonate therapy with those who do not.The population studied, which was part of a prospective bisphosphonate interventional study, consisted of 109 postmenopausal patients with osteoporosis (mean±SD, 67.8±6.3 years). Periodontal assessments at baseline included present teeth, alveolar bone loss (ABL) and community periodontal index (CPI). Mandibular cortical shape was categorized into one of three groups (normal, mildly to moderately eroded or severely eroded) on panoramic radiographs. Fractal dimension (FD) was also measured at periapical sites between canine and premolar of the mandible. Bone mineral density (BMD) of the lumbar spine was assessed by dual energy X-ray absorptiometry. Periodontal parameters between 33 women who use bisphosphonate therapy and 31 women who do not were compared.The mean spine BMD was 0.656±0.075g/cm^2(64.9±7.4% of young adult mean). The mean number of teeth present, mean ABL and FD value were 20.2±8.1, 25.7±9.8% and 1.589±0.034, respectively. The number of subjects with periodontitis (CPI codes 3 or 4), severe attachment loss (AL codes 2, 3 or 4) and eroded mandibular inferior cortex were 103(98.1 %), 67(63.8%) and 97(89.0%). The bisphosphonate therapy inhibited the percentage of teeth with CPI code 3 or 4(P < 0.01) and increased FD value (P < 0.10).These results indicate that postmenopausal osteoporosis may be associated with eroded mandibular cortex and generalized advanced periodontal destruction. Osteoporotic women using bisphosphonate therapy show significantly lower probing depths and greater FD. These observations suggest that bisphosphonate therapy in osteoporotic women may play a beneficial role in periodontal status.

本研究的目的是确定绝经后疏松症的牙周状态和全景放射学测量（皮质形状和下颌骨的皮层形状和分形维度）之间的关系，并比较使用双膦酸盐治疗的人的牙周状态，并比较了他们没有研究的人群。绝经后骨质疏松症患者（平均值±SD，67.8±6.3岁）。基线的牙周评估包括当前的牙齿，牙槽骨质流失（ABL）和社区牙周指数（CPI）。下颌皮质形状分为全景X光片中的三组之一（正常，温和至中度发射或严重发射）。还测量了分形维度（FD）在下颌骨和前磨牙之间的根尖部位。腰椎的骨矿物质密度（BMD）通过双能X射线绝对肽仪评估。 33名使用双膦酸盐治疗的女性与31名未比较的女性之间的牙周参数。平均脊柱BMD为0.656±0.075g/cm^2（64.9±7.4％的年轻成人平均值）。存在的平均牙齿数量，平均ABL和FD值分别为20.2±8.1、25.7±9.8％和1.589±0.034。患有牙周炎的受试者数量（CPI代码3或4），严重的固定损失（AL代码2、3或4）和侵蚀的下颌皮层的数量为103（98.1％），67（63.8％）和97（89.0％）。双膦酸盐治疗抑制了CPI代码3或4（P <0.01）和FD值增加（P <0.10）的牙齿百分比。这些结果表明，绝经后的骨质疏松症可能与侵蚀的下颌皮层和普遍的晚期牙周破坏有关。使用双膦酸盐治疗的骨质疏松妇女的探测深度明显较低，而FD较高。这些观察结果表明，骨质疏松妇女的双膦酸盐治疗可能在牙周地位中起有益的作用。

项目成果

Risk for vertebral osteoporosis in postmenopausal women with alterations of the mandible.

下颌骨改变的绝经后妇女患椎体骨质疏松症的风险。

• 发表时间: 2006
• 期刊: Dentomaxillofac Radiol 17(3)
• 作者: Taguchi A;Ohtsuka M;Tsuda M;Nakamoto T;Kodama I;Inagaki K;Noguchi T;Kudo Y;Suei Y;Tanimoto K.
• 通讯作者: Tanimoto K.

Diagnostic performance of general dental practitioners after lecture in identifying post-menopausal women with low bone mineral density by panoramic radiographs.

全科牙科医生在通过全景X光片识别绝经后女性骨矿物质密度低的讲座后的诊断表现。

• 发表时间: 2006
• 期刊: Dentomaxillofac Radiol. 35(4)
• 作者: Sutthiprapaporn P;Taguchi A;Nakamoto T;Ohtsuka M;Mallick PC;Tsuda M;Kodama I;Kudo Y;Suei Y;Tanimoto K.
• 通讯作者: Tanimoto K.