Development of Extra High Cross-Linkage Structured Resin without Environmental Endocrine Disruptor

无环境内分泌干扰物的超高交联结构树脂的开发

• 批准号: 16390556
• 负责人: TANAKA Jiro
• 金额: $ 9.02万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390556/
• 关键词: Endocrine disrupter; Environmental endocrine disrupter; Estrogenic activity; Cross-linkage; Acidic monomer; Hydrogen bond; Covalent bond; Difunctional monomer; 高分子構造・物性; 生体材料; 架橋密度; 耐水性; 内分泌攪乱作用; ビスフェノール-A; 芳香環; ウレタンジメタクリレート; メタクリル酸; 架橋構造

We have been aimed at the development of a high performance dental matrix resin without the environmental endocrine disruptor. We tried to improve the mechanical properties of resins controlling the cross-linked structure using both of the covalent and hydrogen bonds. As a result, we attained to the synthesis of high performance resin, which is high toughness even with high strength and high rigidity, composed of urethane dimethacrylate (UDMA) and methacrylic acid (MAA). All the mechanical properties of UDMA/MAA resin were superior to those of conventional matrix resins composed of tri(ethylene glycol) dimethacrylate (TEGDMA) as a diluent comonomer in both of Halogen and Xenon light source for photo-polymerization though those of all resins had been changed by the light source. The feature of UDMA/MAA resin was to have had toughness simultaneously with strength and rigidity. Especially, this feature was remarkable in the Xenon light source. Above-mentioned result shows that the mechani … More cal properties of the resin are greatly dependent on the overall structure as well as with the conversion achieved. The heat-treatment after photo-polymerization has been effective to improve the mechanical properties of all resins. The tendency was especially noted in UDMA based resin. After thermo-polymerization, the flexural strength of the UDMA/MAA resin was about 300 MPa while those of the conventional resins composed of TEGDMA were about 200 MPa. The fatigue strength, water durability and wear resistance of UDMA/MAA resin were all more excellent than the conventional resin. Consequently, the UDMA/MAA resin has united all mechanical properties at an extremely high level. In addition, UDMA/MAA resin showed behavior similar to the conventional dental matrix resin on the cell culture. Therefore, UDMA/MAA resin has shown the possibility of replace the conventional dental matrix resins composed of TEGDMA as a diluent comonomer and of appear the high-performance resin based composite materials. Less

我们的目标是开发高性能的牙科基质树脂，而没有环境内分泌破坏者。我们试图改善使用共价键和氢键控制交联结构的树脂的机械性能。结果，我们附着于高性能树脂的合成，即使具有高强度和高刚度，也是高韧性，由氨基甲酸酯二甲基丙烯酸酯（UDMA）和甲基丙烯酸（MAA）组成。 UDMA/MAA树脂的所有机械性能都优于由三（乙二醇）二甲基丙烯酸酯（TEGDMA）组成的常规基质抗性的，作为卤素和异种光源的稀释剂群落，尽管所有树脂都被光源改变了。 UDMA/MAA树脂的特征是，具有强度和刚度很容易具有韧性。特别是，此功能在Xenon Light Source中是显着的。上述结果表明，树脂的更多特性在很大程度上取决于总体结构以及所实现的转换。光聚合后的热处理已有效地改善所有树脂的机械性能。在基于UDMA的树脂中特别注意趋势。热聚合后，UDMA/MAA树脂的弯曲强度约为300 MPa，而由TEGDMA组成的常规树脂的弯曲强度约为200 MPa。 UDMA/MAA树脂的疲劳强度，耐水性和耐磨性都比传统的树脂更出色。因此，UDMA/MAA树脂使所有机械性能都非常高。此外，UDMA/MAA树脂表现出类似于细胞培养的常规牙科基质树脂的行为。因此，UDMA/MAA树脂已经表明可能取代由TeGDMA组成的常规牙科基质抗性，并以高性能树脂基于复合材料而出现。较少的

项目成果

Surface Treatment with N, N'-Dimethacryloylcystine for Enhanced Bonding of Resin on Dental Alloys

N,N-二甲基丙烯酰胱氨酸表面处理增强树脂与牙科合金的结合力

• 发表时间: 2007
• 期刊: Dental Materials Journal 26(in press)
• 作者: Jiro Tanaka;Jeffery W.Stansbury;Joseph M.Antonucci;Kazuomi Suzuki
• 通讯作者: Kazuomi Suzuki

Surface Treatment with N, N'-Dimethacryloylcystine for Enhanced Bonding of Resin to Dental Alloys

用 N,N-二甲基丙烯酰胱氨酸进行表面处理以增强树脂与牙科合金的粘合

• 发表时间: 2006
• 期刊: Dental Materials Journal (in press)
• 作者: Jiro Tanaka;Jeffery W.Stansbury;Joseph M.Antonucci;Kazuomi Suzuki;Marianera Trujillo-Lemon;Marianela Trujillo・Lemon;Jiro Tanaka
• 通讯作者: Jiro Tanaka

Development of High Strength - High Modulus-High Toughness Dental Marix Resin Ability of Urethane Dimethacrylate/Methacrylic Acid Resin -

聚氨酯二甲基丙烯酸酯/甲基丙烯酸树脂的高强度、高模量、高韧性牙科基质树脂能力的开发 -

• 发表时间: 2005
• 期刊: Journal of the Japanese Association for Dental Science 24
• 作者: Marianel Trujillo-Lemon;Junhao Ge;Hui Lu;Jiro Tanaka;Jefery W.Stansbury;Marianela Trujillo-Lemon;Yamamoto T;田仲持郎;Lewis JB;Jiro Tanaka
• 通讯作者: Jiro Tanaka

内分泌撹乱物質を含まない高強度・高弾性・高靭性歯科用レジンの開発 -ウレタンジメタクリレート/メタクリル酸レジンの可能性-

开发不含内分泌干扰物的高强度、高弹性、高韧性牙科树脂 - 聚氨酯二甲基丙烯酸酯/甲基丙烯酸树脂的可能性 -

• 发表时间: 2005
• 期刊: 日本歯科医学会誌 24
• 作者: Marianel Trujillo-Lemon;Junhao Ge;Hui Lu;Jiro Tanaka;Jefery W.Stansbury;Marianela Trujillo-Lemon;Yamamoto T;田仲持郎
• 通讯作者: 田仲持郎

内分泌撹乱物質を含まない高強度・高弾性・高靭性歯科用レジンの開発

开发不含内分泌干扰物的高强度、高弹性、高韧性牙科树脂

• 发表时间: 2004
• 期刊: 日本歯科医学会誌 23
• 作者: Tsuchimoto.Y.;Yoshida;Y.et al.;Hsu S;田仲持郎
• 通讯作者: 田仲持郎