Individual susceptibility to chemical substances

个体对化学物质的敏感性

• 批准号: 16390181
• 负责人: YOKOYAMA Kazuhito
• 金额: $ 9.6万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390181/
• 关键词: Chemical substance; Health effects; Neuro behavioral medicine; Neuro physiology; Micro nuclei test; DNA addict; Polymor phism; P450; NA付加体

Subjects in the development building of sick house, and workers with chemical exposures were surveyed for the purpose of clarifying the gene cluster relevant to the individual differences of the sensibility. Investigation items were neurophysiological and behavioral changes as well as genotoxicitic effects (micro nuclei test). The gene clusters made into the object of analysis by this research were those belonging to the sub family of the cytochrome P-450 in connection with chemicals metabolism, and a DNA repair genes which participates in restoration of DNA damaged by chemicals exposure. This aimed at construction of the monitoring system which can judge synthetically the individual differences of the sensibility about effects of chemicals. That is, it was analyzed synthetically how a gene pleiotype factor would be concerned with change (individual differences of sensibility) of an exposure index, or a neurotoxicity and a genetic toxicity influence index, making full use of the mathematical statistics-procedure. Report were performed at scientific meetings, while creating the original paper to the international journals. The above results were summarized for the result report (booklet object).

对病房的开发建设的受试者和具有化学暴露的工人进行了调查，目的是阐明与敏感性个体差异相关的基因簇。研究项目是神经生理学和行为变化以及遗传毒性作用（微核测试）。这项研究将基因簇变成分析对象的是与化学药品代谢相关的细胞色素P-450子家族的基因簇，以及参与化学物质暴露受损的DNA的DNA修复基因。这旨在构建监测系统，该系统可以综合地判断化学物质影响的敏感性的个体差异。也就是说，通过合成分析了基因多构型因子如何与暴露指数的变化（敏感性的个体差异）或神经毒性和遗传毒性影响指数有关，从而充分利用了数学统计统计量化。报告是在科学会议上进行的，同时撰写了国际期刊的原始论文。结果报告总结了上述结果（小册子对象）。

项目成果

A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

• DOI: 10.1016/j.mrfmmm.2006.02.004
• 发表时间: 2006-07
• 期刊: Mutation research
• 作者: H. Ishikawa;Takashi Ishikawa;Yu Miyatsu;Kazuo Kurihara;A. Fukao;K. Yokoyama

Effects of urbanization, economic development, and migration of workers on suicide mortality in Japan

• DOI: 10.1016/s0277-9536(03)00285-5
• 发表时间: 2004-03-01
• 期刊: SOCIAL SCIENCE & MEDICINE
• 影响因子: 5.4
• 作者: Otsu, A;Araki, S;Voorhees, AS
• 通讯作者: Voorhees, AS

Effects of static load on the weight and protein content in the muscles of the mouse : a simulation of prolonged standing in the workplace

静负荷对小鼠体重和肌肉蛋白质含量的影响：模拟在工作场所长时间站立

• 发表时间: 2004
• 期刊: Industrial Health 42
• 作者: Ueno;S.
• 通讯作者: S.

Decreases in CD8+T, na□ve (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume.

暴露于锰烟后 CD8+T、幼稚 (CD4+CD45RA+) T 和 B (CD19+) 淋巴细胞减少。

• 发表时间: 2006
• 期刊: Industtrial Health 44
• 作者: Nakata;A.
• 通讯作者: A.

Teratogenecity and developmental toxicity of chlorpyrifos : maternal exposure during organogenesis in mice.

毒死蜱的致畸性和发育毒性：小鼠器官发生期间的母体暴露。

• 发表时间: 2005
• 期刊: Reproductive Toxicology 20
• 作者: Tian;Y.
• 通讯作者: Y.