Assessment of cerebellar, vestibular and spinocerebellar effects of various factors using posuturography

使用姿势描记法评估各种因素对小脑、前庭和脊髓小脑的影响

• 批准号: 08457127
• 负责人: YOKOYAMA Kazuhito
• 金额: $ 4.74万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457127/
• 关键词: Posturography; Computer; Frequecncy analysis; Lead; Solvents; Cerebellar; Vestibular; Sarin

To examine the effects of occupational and environmental factors such as lead, organic solvents (n-hexane, xylene and toluene) and sarin on vestibular, cerebellar and spinocerebellar afferent system using a computerized posturography with sway frequency analysis. The following three groups of subjects were examined : (1) 49 male chemical factory workers exposed to lead stearate, aged 27-63 (mean 43) years, with concurrent blood lead concentrations (BPhs) of 11-113 (mean 48) mug/10Og and past mean BPbs of 7-52 (mean 24) mug/100g ; (2) 29 male sandal, shoe and leather factory workers, aged 35-73 (mean 51) years, with urinary concentrations of 2,5-hexanedione (HD) of 0.41-3.06 (mean 1.20) mg/g creatinine ; and (3) 9 males and 9 females, aged 19-58 (mean 31) years, who exposed to accidentally sarin by a presumed terrorist attack (Tokyo Subway Sarin Poisoning, March 20, 1995) and showed plasma cholinesterase (ChE) of 13-131 (mean 72) IU/1 6-8 months before the study. Control subjects for th … More e three groups were "healthy" volunteers composed of (1) 23 males, (2) 22 males, and (3) 31 males and 24 females, respectively. Postural balance was measured using a force platform connected to a microcomputer. Power of the sway for each frequency domain was calculated by the FFT method ; length and area of the sway path were measured ; and Romberg quotients (RQs, eyes-closed to eyes-open ratios) for each sway measures were determined.In lead workers, the postural sway of high (2-4 Hz) and low (0-1 Hz) frequencies with eyes open and closed were significantly increased. The sway of 0.5-2 Hz with eyes open was significantly related to concurrent BPb ; whereas the sway of high frequency with eyes closed was related to past mean BPb. In organic solvent workers, the high frequency sway with eyes closed was significantly increased ; 1-4 Hz sway with eyes open was related positively to HD and inversely to methylhippurinc acid concentrations in urine. In female sarin poisoning patients, low frequency sway with eyes open was significantly increased. RQs for low frequency sway were significantly correlated with log ChE in both male and female poisoning patients.The pattern of the posturographic changes suggested that the vestibulo- cerebellum, anterior cerebellar lobe and spinocerebellar afferent were asymptomatically affected by lead ; the vestibulo-cerebellar change reflected concurrent lead absorption and the anterior cerebellar one reflected past absorption. Similarly, the vestibulo-cerebellar and spinocerebellar afferent function was affected by n-hexane ; the effect on vestibulo-cerebellar function was possibly inhibited by xylene. The chronic (long-term) vestibulo-cerebellar effect was considered to be induced by acute sarin poisoning ; females might be more susceptible than males. The computerized posturography with frequency analysis seems useful for assessment of vestibular, cerebellar and spinocerebellar afferent function. Less

为了检查职业和环境因素，例如铅，有机溶液（N-己烷，二甲苯和甲苯）以及沙林对前庭，小脑和脊椎动物传入系统的影响，并使用SWWAY频率分析的计算机化姿势。检查了以下三组受试者：（1）49名男性化学厂工人，暴露于27-63岁（平均43）年的铅铅酸盐，同时血液铅浓度（BPH）为11-113（平均48）杯/10OG，平均BPB为7-52（平均24）MUG/100G； （2）29名男性凉鞋，鞋子和皮革工厂工人，年龄35-73岁（平均51）年，尿液浓度为2,5-己二酮（HD）为0.41-3.06（平均1.20）mg/g肌酐； （3）9-58岁（平均31岁）的9名男性和9名女性，他们因预览的恐怖袭击而意外地暴露于沙林（Tokyo Subway sarin Doicuning，1995年3月20日），并显示了研究前13-131（平均72）IU/1 6-8个月的血浆胆碱酯酶（CHE）。对照受试者，更多的E三组是由（1）23名男性，（2）22名男性和（3）男性和31位男性和24名女性组成的“健康”志愿者。使用连接到微型计算机的力平台测量姿势平衡。通过FFT方法计算每个频域的跑道的功率；测量摇摆路径的长度和面积；确定了每种摇摆测量值的Romberg报价（RQ，眼睛闭合至开眼的比率）。在主要工作人员中，高（2-4 Hz）和低（0-1 Hz）的姿势摇摆，眼睛张开和闭合的频率显着增加。睁开眼睛的0.5-2 Hz的摇摆与并发的BPB显着相关。而闭合眼睛的高频摇摆与过去的平均BPB有关。在有机偿付能力工人中，高频闭合的高频摇摆显着增加。 1-4 Hz睁开眼睛的摇摆与HD呈正相关，并与尿液中的甲基硫酸甲基酸浓度成反。在女性沙林中毒患者中，低频睁开眼睛的摇摆显着增加。在男性和女性中毒患者中，与log CHE的RQS显着增加了。图后变化的模式表明，前庭脑，小脑前叶和脊椎队的传入受到铅的不对称影响；前庭脑的变化反映了并发的铅滥用，而前小脑反映了过去的滥用。类似地，前庭cere骨和脊椎动物传入功能受到n-己烷的影响。二甲苯可能抑制对前庭核能功能的影响。慢性（长期）前庭效应被认为是由急性沙林中毒诱导的。女性可能比男性更容易受到影响。带有频率分析的计算机化姿势似乎有助于评估前庭，小脑和脊髓杆菌传入功能。较少的

项目成果

Yokoyama,K.: "Subclinical vestibulo-cerebellar,entirior cerebellar lobe and spinocerebellar effects in lead workers in relation to concurrent and past exposure" Neurotoxicology. (in press).

Yokoyama，K.：“与同时和过去暴露相关的领导人员的亚临床前庭小脑、小脑全叶和脊髓小脑效应”神经毒理学。

Fujimura,Y.: "Changes in the distribution of nerve conduction volocities in diabetics" Tohoku Journal of Experimental Medicine. 178. 177-185 (1996)

Fujimura,Y.：“糖尿病患者神经传导波动分布的变化”东北实验医学杂志。

Yokoyama,K.,Araki,S.,et al: "Chronic neuro-behavioral effects of Tokyo subway sarin poisoning in relation to posltraumatic stress disorder." Archives of Environmental Health. 53. 249-256 (1998)

Yokoyama,K.、Araki,S.等人：“东京地铁沙林中毒与创伤后应激障碍相关的慢性神经行为影响。”

Murata,K.: "Accumulation of VDT work-related visual fatigue assessed by visual evoked potential,near point distance and critical flicker fusion" Industrial Health. 34. 61-61 (1996)

Murata,K.：“通过视觉诱发电位、近点距离和临界闪烁融合评估 VDT 工作相关视觉疲劳的累积”工业健康。

荒記俊一: "環境因子による非顕性の神経・精神行動障害の評価方法と最近の知見" 日本衛生学雑誌. 50. 713-729 (1995)

Shunichi Araki：“环境因素引起的亚临床神经和心理行为障碍的评估方法和最新发现”日本卫生杂志 50. 713-729 (1995)。