Elucidation of Disintegration Mechanism of Microcapsules including a Gas Bubble and Nano-particles for Drug Delivery in Blood Flows Using Underwater Shock Waves

利用水下冲击波阐明用于血流中药物输送的包含气泡和纳米颗粒的微胶囊的崩解机制

基本信息

批准号：
16360092
负责人：
TAMAGAWA Masaaki
金额：
$ 8.58万
依托单位：
Kyushu Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

In this study, our aim is to investigate this mechanism and apply the shock wave technology to disintegrate cell in the bioprocess industry and medical field such as Drug Delivery Systems (DDS). In this project, especially, the following important things for applying to DDS were investigated(A-1) Stimulus of the capsule and the cell near the arterial wall and thrombus in the shock wave DDS.(A-2) Establishment of disintegration of microcapsule and stimulus of the cell by shock waveThe results about these topics are obtained as follows;(A-1) The stimulus of shock waves on the cell increases the growth rate of the cell number in case of endothelial cells. Although this result shows possibility of decreasing the effects of anti-cancer, it is possible to optimize two parameters such as disintegration and cell-growth because the growth rate is dependent on the rise frequency and amplitude of pressure wave (shock wave)(A-2) To apply theoretical model of the shock wave propagation to the cell, … More the cell model was composed of three structures such as the surrounding fluid, cell membrane and internal fluid. Using these models, the stress and pressure wave on the membrane and in the cell were analyzed in case of working underwater shock wave on the cell. As a result, the higher the rising frequency becomes high, the larger the stress wave on the cell increases. Then it was found that the effect of frequency on the stimulus is high.For the development of generating shock wave method, the following two things are investigated as the actual application;(B-1) Generation of shock wave using Laser(B-2) Development of small scale microcapsule including a gas bubble and measurement of their mechanical properties.The results about these topics are obtained as follows;(B-1) The generation method of shock wave using Yag Laser was established, but energy loss in the part of optical coupling between optical fiber and lens is high and the stability of shock wave generation was not good. So the method to introduce the shock wave in the test water tank will be changed, then the laser beam will be directly to the water tank system.(B-2) The special microcapsules composed of gas bubble, liquid, capsule membrane can be obtained, and the diameter size of them is 20-30 μm. This size is 30% of the previous investigation up to 2003, and it is found that these size is applicable to use as bladder DDS in human body. Less

在这项研究中，我们的目的是调查这种机制，并将冲击波技术应用于生物处理行业和医疗领域（例如药物输送系统（DDS））中的细胞。尤其是，在该项目中，研究了以下重要事项（A-1）刺激胶囊和动脉壁附近的细胞和电动壁中的细胞。内皮细胞。尽管该结果表明可能会降低抗癌的影响，但可以优化两个参数，例如分解和细胞增长，因为生长速率取决于压力波（冲击波）（冲击波）（A-2）的上升频率和放大器以将冲击波传播的理论模型应用于电池，以下是细胞模型的内部元素，例如三个结构的流动性，例如流动性的流动性。使用这些模型，在细胞上工作的水下冲击波时，分析了膜和细胞中的应力和压力波。结果，上升频率变得越高，细胞上的应力波越大。然后发现频率对刺激的影响很高。对于产生冲击波方法的开发，以下两件事被研究为实际应用；（b-1）使用激光（B-2）开发小型微型泡沫的产生冲击波（B-2），包括气泡和包括其机械性能的涉及这些主题的结果。涉及这些主题的结果。光纤和镜头之间的光学耦合很高，冲击波产生的稳定性不好。因此，将更改在测试水箱中引入冲击波的方法，然后激光束将直接进入水箱系统。（B-2）特殊的微胶囊，由气泡，液体，胶囊膜组成，并且可以获得胶囊膜，并且它们的直径尺寸为20-30μm。这种规模是截至2003年之前投资的30％，发现这些尺寸适用于用作人体膀胱DDS。较少的