Development of new medical gel materials using synthetic carbohydrate polymer

使用合成碳水化合物聚合物开发新型医用凝胶材料

基本信息

批准号：
16300146
负责人：
KAKUCHI Toyoji
金额：
$ 9.66万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300146/
关键词：
Cellulose Hyperbranched Carbohydrate Polymer Gel Hemostat Sealant Polycarbohydrate Derivative

项目摘要

Gel-materials, such as gelatin, collagen, and fibrinogen, derived from animals and humans, have been used widely in medical applications, although the materials include the possibilities of the contagions of a virus and an allergic material. We recently discovered that a novel carbohydrate polymer having a specific structure formed a new class of gel-material. Depending on the formulation and preparation method, materials ranging from viscous liquids, soft gels, and tough films can be obtained with widely varying gel formation kinetics. Since the starting materials are classified as biocompatible and biodegradable, this new class of gels has many potential medical applications, such as hemostatic, adhesive, and coating agents. Carbohydrate polymers having a specific structure can be synthesized from naturally occurring sugars or compounds microwave-decomposed from polysaccharide. The novel carbohydrate polymers have characteristics as follows ; 1)basic materials for medical applications at a reasonable cost, 2)easy control of the chemical and physical properties, 3)biocompatible and biodegradable materials. The reaction of the carbohydrate polymer with a gelling agent immediately forms the gel-materials, which offers several advantages over conventional gel preparations, including the use of non-contagion materials and short preparation times. The gel-materials are a versatile new class of biomaterials that hold promise for a wide variety of medical applications.

源自动物和人类的凝胶材料，例如明胶、胶原蛋白和纤维蛋白原，已广泛用于医疗应用，尽管这些材料包括病毒和过敏材料传染的可能性。我们最近发现一种具有特定结构的新型碳水化合物聚合物形成了一类新型凝胶材料。根据配方和制备方法，可以获得从粘性液体、软凝胶到坚韧薄膜的材料，其凝胶形成动力学差异很大。由于起始材料被归类为生物相容性和可生物降解性，这种新型凝胶具有许多潜在的医疗应用，例如止血剂、粘合剂和涂层剂。具有特定结构的碳水化合物聚合物可以由天然存在的糖或多糖微波分解的化合物合成。新型碳水化合物聚合物具有以下特点： 1）成本合理的医疗应用基础材料，2）化学和物理性能易于控制，3）生物相容性和可生物降解材料。碳水化合物聚合物与胶凝剂的反应立即形成凝胶材料，与传统的凝胶制剂相比，它具有多种优点，包括使用非传染性材料和短的制备时间。凝胶材料是一种多功能的新型生物材料，有望用于各种医疗应用。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Synthesis and Photocrosslinking Reaction of N-Allylcarbamoylmethyl Cellulose Leading to Hydrogel

N-烯丙基氨基甲酰甲基纤维素的合成及光交联反应生成水凝胶

DOI：
发表时间：
2006
期刊：
Polym. Bull. 56・2-3
影响因子：
0
作者：
Shinoda Y;Sugiuchi Y;Izawa Y;Hata Y;Xiande Shen
通讯作者：
Xiande Shen

Synthesis of hyperbranched carbohydrate polymer by ring-opening multibranching polymerization of 1,4-anhydroerythritol and 1,4-anhydro-L-threitol

DOI：
10.1021/ma0358024
发表时间：
2004-05-04
期刊：
MACROMOLECULES
影响因子：
5.5
作者：
Imai, T;Satoh, T;Kakuchi, T
通讯作者：
Kakuchi, T

Synthesis, Branched Structure, and Solution Property of Hyperbranched d-Glucan and d-Galactan

DOI：
10.1021/ma0475479
发表时间：
2005-04
期刊：
Macromolecules
影响因子：
5.5
作者：
T. Satoh;T. Imai;Hiroyuki Ishihara;Takahiro Maeda;Y. Kitajyo;Y. Sakai;H. Kaga;Noriaki Kaneko;F. Ishii;T. Kakuchi
通讯作者：
T. Satoh;T. Imai;Hiroyuki Ishihara;Takahiro Maeda;Y. Kitajyo;Y. Sakai;H. Kaga;Noriaki Kaneko;F. Ishii;T. Kakuchi

Synthesis of Hyperbranched Polytetritol by Ring-Opening Multibranching Polymerizations of 2,3-Anhydroerythritol and 2,3-Anhydro-dl-threitol