Study of Sexual Function in Middle High Aged Male

中老年男性性功能研究

• 批准号: 02404065
• 负责人: KUMAMOTO Yoshiaki
• 金额: $ 5.18万
• 依托单位: Sapporo Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404065/
• 关键词: male "climacterium"; unidentified complaints syndrome; penile vascular disorder; penile neurological disorder; decrease of dopamine level in brain; 性は脳なり; 札幌大式性機能質問調査用紙; 加齢性性機能低下; 糖尿病性性機能低下; 腎障害性性機能低下; 脳内ド-パミン; 脳内アセチ-ルコリン; 性機能; ストレス; ド-パミン

As we have been reaching to high age society, medical interest has focused on the quality of life in the aged people. In this connection, a maintenance of male sexual function has been a topic of society. However, when we discussed male sexual dysfunction of the aged people, we need a data on standard of the sexual function by age in Japanese people. Thus, we conducted a survey on sexual function of male, of which results showed that the male sexual function gradually declined at the age of 50. The study on factors which accelerate male sexual dysfunction in "climacterium" revealed that psycological stress played an important role in the dysfunction. The decline of male sexual function correlated with a severity of unidentified complaints syndrome, which are often seen in"female climacterium".We were able to identify in experimental studies in rat that male sexual dysfunction may depend on a decrease of dopamine level in hypothalamic area, particularly, sex center, the decrease which w … More ere also accelerated by psychological stress. Penile-vacular disorder was revealed to be the most influential factor on gradually and physiologically progressive decrease of sexual function in the aged people of more than 60. Neurological disorder was an influential factor. However, in patients with diabetes or those receiving dialysis, they were found to have not only more accelerated penile vascular disorder but also severe neurological dysfunction. It should be emphasized that sexual dysfunction in aged male is often associated with disorder of peripheral organs and also with a decrease of dopamine level in the brain, which is seen in "male climacterium". Since a positive correlation of dopamine level with serum testosterone is commonly found, testicular endocrine dysfunction by age seems indirectly to influence on sexual dysfunction in the aged people.Thus, an administration of l-dopa on the aged improved to some extent the sexual dysfunction, suggesting that dopamine level is partly related to the sexual dysfunction in the aged people. Less

随着社会进入高龄化阶段，医学关注焦点集中在老年人的生活质量上，因此，男性性功能的维护已成为社会的话题。对于老年人，我们需要日本人不同年龄的性功能标准的数据，因此，我们对男性性功能进行了调查，结果显示，男性性功能在50岁时逐渐下降。加速男性性功能障碍的因素“更年期”揭示了心理压力在功能障碍中发挥了重要作用。男性性功能下降与不明原因症状的严重程度相关，这种症状常见于“女性更年期”。我们在大鼠实验研究中发现了这一点。男性性功能障碍可能取决于下丘脑区域（特别是性中心）多巴胺水平的下降，而心理压力也会加速这种下降，这也是影响最大的因素。 60岁以上老年人性功能逐渐、生理性进行性下降的因素之一。神经系统疾病是一个影响因素，但在糖尿病患者或接受透析的患者中，发现他们不仅更容易出现阴茎血管疾病，而且还会加速。还需要强调的是，老年男性的性功能障碍往往与周围器官的紊乱有关，也与大脑中多巴胺水平的降低有关，这见于“男性更年期”，因为多巴胺呈正相关。等级随着血清睾酮水平的升高，睾丸内分泌功能障碍似乎会间接影响老年人的性功能障碍。因此，老年人服用左旋多巴可以在一定程度上改善性功能障碍，提示多巴胺水平部分相关老年人性功能障碍较少。